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WNK4 Antibody (PA1-16878) in WB
Western blot analysis of WNK4 in whole cell protein from Hek293. Samples were incubated in WNK4 polyclonal antibody (Product # PA1-16878) using a dilution of 2 µg/mL followed by an anti-rabbit HRP secondary antibody. Separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. Detection: chemiluminescence.
产品信息
PA1-16878
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region of human WNK4 between residues 200-300.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2216996
产品详细信息
This antibody is not recommended for ICC/IF applications.
Suggested positive control: mouse kidney lysate or protein.
靶标信息
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Protein kinase lysine-deficient 4; Protein kinase with no lysine 4; protein kinase, lysine deficient 4; protein kinase, lysine-deficient 4; RP23-281C18.8; Serine/threonine-protein kinase WNK4; WNK4 Ser/Thr kinase
基因别名: 2010002J11Rik; Ac2-059; PHA2B; PRKWNK4; WNK4
UniProt ID: (Human) Q96J92, (Mouse) Q80UE6, (Rat) Q7TPK6
Entrez Gene ID: (Human) 65266, (Mouse) 69847, (Rat) 287715
protein phosphorylation
ion transport
chloride transport
protein localization
positive regulation of ion transmembrane transporter activity
intracellular signal transduction
regulation of cellular process
ion homeostasis
renal sodium ion absorption
distal tubule morphogenesis
negative regulation of pancreatic juice secretion
regulation of ion homeostasis
phosphorylation
cellular chloride ion homeostasis
