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产品信息
MA5-15544
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
10C8
抗原
Purified recombinant fragment of WNT1 expressed in E. Coli.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.03% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_10984682
产品详细信息
MA5-15544 targets WNT1 in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human and mouse samples.
The MA5-15544 immunogen is purified recombinant fragment of WNT1 expressed in E. Coli.
MA5-15544 detects WNT1 which has a predicted molecular weight of approximately 41kDa.
靶标信息
Wnt proteins constitute a family of secreted glyocoproteins that activate signal transduction pathways to mediate tissue homeostasis, cell fate, cell proliferation, and self-renewal. The canonical signaling pathway is initiated upon Wnt binding to a Frizzled family receptor and an LRP5/LRP6 coreceptor, which leads to activation of the beta-catenin cascade. Non-canonical Wnt signals are activated by binding to a Frizzled family receptor and ROR2 coreceptor. Extensive research has shown that deregulation of these pathways or its components can lead to cancer. Human Wnt-1 is encoded as a 370 amino acid precursor that, upon secretion, is cleaved into a 343 amino acid (42 kDa) mature form. At the amino acid level, mature human Wnt-1 is approximately 99% identical to mature mouse Wnt-1. Depending on the tissue, Wnt-1 can activate the canonical and non-canonical signaling pathways. Studies have demonstrated its involvement in a variety of functions, including embryonic development and carcinogenesis. Wnt-1 signaling can also induce the phosphorylation and subsequent degradation of c-Myb.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Proto-oncogene Int-1; Proto-oncogene Int-1 homolog; proto-oncogene protein Wnt-1; Proto-oncogene Wnt-1; wingless-related MMTV integration site 1; wingless-type MMTV integration site family member 1; wingless-type MMTV integration site family, member 1 (oncogene INT1)
基因别名: BMND16; Int-1; INT1; OI15; sw; swaying; Wnt-1; WNT1
UniProt ID: (Human) P04628, (Mouse) P04426
Entrez Gene ID: (Human) 7471, (Mouse) 22408
embryonic axis specification
branching involved in ureteric bud morphogenesis
positive regulation of protein phosphorylation
cell-cell signaling
myoblast fusion
positive regulation of cell proliferation
response to wounding
positive regulation of lamellipodium assembly
negative regulation of cell-substrate adhesion
Wnt signaling pathway
spinal cord association neuron differentiation
diencephalon development
central nervous system morphogenesis
cerebellum formation
forebrain anterior/posterior pattern specification
midbrain-hindbrain boundary maturation during brain development
negative regulation of cell-cell adhesion
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
ubiquitin-dependent SMAD protein catabolic process
midbrain development
organ regeneration
T cell differentiation in thymus
cell proliferation in midbrain
inner ear morphogenesis
signal transduction in response to DNA damage
positive regulation of insulin-like growth factor receptor signaling pathway
canonical Wnt signaling pathway involved in negative regulation of apoptotic process
cell fate commitment
negative regulation of fat cell differentiation
positive regulation of Notch signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
neuron fate determination
neuron development
positive regulation of sequence-specific DNA binding transcription factor activity
Spemann organizer formation
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
bone development
positive regulation of dermatome development
hepatocyte differentiation
cellular response to peptide hormone stimulus
hematopoietic stem cell proliferation
positive regulation of canonical Wnt signaling pathway
negative regulation of cell aging
beta-catenin destruction complex disassembly
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
embryonic brain development
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
signal transduction
multicellular organism development
organ morphogenesis
myotube differentiation
metencephalon development
BMP signaling pathway
midbrain-hindbrain boundary development
negative regulation of cell differentiation
neuron fate commitment
