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产品信息
PA5-87034
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein of human WNT4.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2803788
产品详细信息
Purity is > 95% by SDS-PAGE.
靶标信息
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.
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生物信息学
蛋白别名: Protein Wnt-4; signal molecule; wingless-related MMTV integration site 4; wingless-type MMTV integration site family member 4; wingless-type MMTV integration site family, member 4
基因别名: SERKAL; UNQ426/PRO864; WNT-4; WNT4
UniProt ID: (Human) P56705, (Rat) Q9QXQ5, (Mouse) P22724
Entrez Gene ID: (Human) 54361, (Rat) 84426, (Mouse) 22417
branching involved in ureteric bud morphogenesis
kidney development
epithelial to mesenchymal transition
embryonic epithelial tube formation
liver development
androgen biosynthetic process
male gonad development
female gonad development
cellular response to starvation
negative regulation of gene expression
negative regulation of steroid biosynthetic process
Wnt signaling pathway
regulation of cell-cell adhesion
neuron differentiation
female sex determination
adrenal gland development
negative regulation of cell migration
positive regulation of bone mineralization
positive regulation of aldosterone biosynthetic process
positive regulation of collagen biosynthetic process
immature T cell proliferation in thymus
non-canonical Wnt signaling pathway via MAPK cascade
negative regulation of fibroblast growth factor receptor signaling pathway
positive regulation of GTPase activity
cell fate commitment
negative regulation of cell differentiation
positive regulation of osteoblast differentiation
positive regulation of meiotic nuclear division
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
oocyte development
smooth muscle cell differentiation
positive regulation of stress fiber assembly
positive regulation of focal adhesion assembly
canonical Wnt signaling pathway
somatotropin secreting cell differentiation
thyroid-stimulating hormone-secreting cell differentiation
mesenchymal to epithelial transition
tertiary branching involved in mammary gland duct morphogenesis
negative regulation of wound healing
mammary gland epithelium development
positive regulation of dermatome development
paramesonephric duct development
negative regulation of testicular blood vessel morphogenesis
cellular response to transforming growth factor beta stimulus
renal vesicle formation
renal vesicle induction
metanephric mesenchymal cell differentiation
metanephric tubule formation
metanephric nephron morphogenesis
establishment of protein localization to plasma membrane
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
negative regulation of male gonad development
positive regulation of cortisol biosynthetic process
negative regulation of testosterone biosynthetic process
negative regulation of apoptotic signaling pathway
metanephros development
mesonephros development
gamete generation
sex differentiation
protein palmitoylation
cell differentiation
response to estradiol
T cell differentiation in thymus
tube morphogenesis
non-canonical Wnt signaling pathway
hormone metabolic process
branching morphogenesis of an epithelial tube
anatomical structure development
kidney morphogenesis
cellular response to estradiol stimulus
cellular response to hydrostatic pressure
nephron development
mesonephric tubule development
metanephric nephron development
signal transduction
cell-cell signaling
multicellular organism development
