Invitrogen

ZC3H12A Polyclonal Antibody

查看其他7个ZC3H12A抗体

抗体检测数据 (2)

ZC3H12A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ZC3H12A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ZC3H12A Antibody (PA5-115556) in IHC (P)

Immunohistochemistry analysis of ZC3H12A in human kidney cancer and adjacent normal tissues. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115556) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.

ZC3H12A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ZC3H12A Antibody in Western Blot (WB)

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ZC3H12A Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of ZC3H12A in human kidney cancer and adjacent normal tissues. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115556) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.

ZC3H12A Antibody in Western Blot (WB) — Western blot analysis of ZC3H12A in A431 cells lysate (left lane: treated with blocking peptide). Samples were incubated with polyclonal antibody (Product # PA5-115556).

产品信息

PA5-115556

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

-

免疫组化（石蜡） (IHC (P))

1:50-1:200

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human ZC3H12A(Accession Q5D1E8), corresponding to amino acid residues V222-D272.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2900191

产品详细信息

Antibody detects endogenous levels of total MCPIP1.

靶标信息

ZC3H12A is an MCP1 -induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Endoribonuclease ZC3H12A; MCP-1 treatment-induced protein; MCP-induced protein 1; Monocyte chemotactic protein-induced protein 1; Reg1; Regnase-1; ribonuclease ZC3H12A; RP3-423B22.1; zc3h12a; zc3h12a {ECO:0000312|RGD:1306776}; Zinc finger CCCH domain-containing protein 12A

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基因别名: BC036563; dJ423B22.1; MCPIP; MCPIP1; RGD1306776; ZC3H12A

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UniProt ID: (Human) Q5D1E8, (Rat) A0JPN4, (Mouse) Q5D1E7

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Entrez Gene ID: (Human) 80149, (Rat) 313587, (Mouse) 230738

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DNA binding chromatin binding RNA binding mRNA binding mRNA 3'-UTR binding endoribonuclease activity exoribonuclease activity ribonuclease activity thiol-dependent ubiquitin-specific protease activity protein binding miRNA binding RNA stem-loop binding mRNA 3'-UTR AU-rich region binding ribosome binding metal ion binding endonuclease activity nuclease activity hydrolase activity phosphoric ester hydrolase activity T/G mismatch-specific endonuclease activity retroviral 3' processing activity endoribonuclease

参与通路

nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay angiogenesis negative regulation of protein phosphorylation positive regulation of defense response to virus by host transcription, DNA-templated apoptotic process inflammatory response cellular response to DNA damage stimulus nervous system development regulation of gene expression positive regulation of autophagy positive regulation of endothelial cell migration positive regulation of gene expression negative regulation of gene expression negative regulation of muscle cell apoptotic process positive regulation of lipid storage positive regulation of cell death protein deubiquitination cell differentiation negative regulation of NF-kappaB transcription factor activity negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production cellular response to oxidative stress cellular response to glucose starvation positive regulation of protein import into nucleus negative regulation of NF-kappaB import into nucleus negative regulation of macrophage activation negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation by host of viral genome replication negative regulation of nitric oxide biosynthetic process positive regulation of fat cell differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter negative regulation of interleukin-1 beta secretion protein oligomerization defense response to virus negative regulation of cardiac muscle contraction positive regulation of mRNA catabolic process 3'-UTR-mediated mRNA destabilization cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to tumor necrosis factor RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic RNA phosphodiester bond hydrolysis, exonucleolytic cellular response to virus negative regulation of cytokine production involved in inflammatory response positive regulation of execution phase of apoptosis negative regulation of interleukin-6 secretion positive regulation of p38MAPK cascade negative regulation of interferon-gamma secretion positive regulation of protein deubiquitination negative regulation of production of miRNAs involved in gene silencing by miRNA cellular response to sodium arsenite negative regulation of tumor necrosis factor secretion cellular response to phorbol 13-acetate 12-myristate cellular response to ionomycin cellular response to chemokine positive regulation of reactive oxygen species metabolic process positive regulation of miRNA catabolic process nucleic acid phosphodiester bond hydrolysis multicellular organism development