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ZC3H12A Antibody (PA5-83216) in WB
Western blot was performed using Anti-ZC3H12A Polyclonal Antibody (Product # PA5-83216) and a ~65 kDa band corresponding to Endoribonuclease ZC3H12A was observed across cell lines tested. Whole cell extracts (50 µg lysate) of RAW 264.7 (Lane 1), RAW 264.7 treated with LPS 100 ng/mL for 12h (Lane 2), SK-O-V3 (Lane 3), Raji (Lane 4), SH-SY5Y (Lane 5), IMR-32 (Lane 6) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # LC2001) by... View More
产品信息
PA5-83216
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Anitgen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2790372
产品详细信息
Immunogen sequence: CTYGIKCRFF HPERPSCPQR SVADELRANA LLSPPRAPSK DKNGRRPSPS SQSSSLLTES EQCSLDGKKL GAQASPGSRQ EGLTQTYAPS GRSLAP
靶标信息
ZC3H12A is an MCP1 -induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Endoribonuclease ZC3H12A; MCP-1 treatment-induced protein; MCP-induced protein 1; Monocyte chemotactic protein-induced protein 1; Reg1; Regnase-1; ribonuclease ZC3H12A; RP3-423B22.1; Zinc finger CCCH domain-containing protein 12A
基因别名: dJ423B22.1; MCPIP; MCPIP1; ZC3H12A
UniProt ID: (Human) Q5D1E8
Entrez Gene ID: (Human) 80149
DNA binding
chromatin binding
RNA binding
mRNA binding
mRNA 3'-UTR binding
endoribonuclease activity
exoribonuclease activity
ribonuclease activity
thiol-dependent ubiquitin-specific protease activity
protein binding
miRNA binding
RNA stem-loop binding
mRNA 3'-UTR AU-rich region binding
ribosome binding
metal ion binding
endoribonuclease
nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
angiogenesis
negative regulation of protein phosphorylation
positive regulation of defense response to virus by host
transcription, DNA-templated
apoptotic process
inflammatory response
cellular response to DNA damage stimulus
nervous system development
regulation of gene expression
positive regulation of autophagy
positive regulation of endothelial cell migration
positive regulation of gene expression
negative regulation of gene expression
negative regulation of muscle cell apoptotic process
positive regulation of lipid storage
positive regulation of cell death
protein deubiquitination
cell differentiation
negative regulation of NF-kappaB transcription factor activity
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
cellular response to oxidative stress
cellular response to glucose starvation
positive regulation of protein import into nucleus
negative regulation of NF-kappaB import into nucleus
negative regulation of macrophage activation
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation by host of viral genome replication
negative regulation of nitric oxide biosynthetic process
positive regulation of fat cell differentiation
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
negative regulation of interleukin-1 beta secretion
protein oligomerization
defense response to virus
negative regulation of cardiac muscle contraction
positive regulation of mRNA catabolic process
3'-UTR-mediated mRNA destabilization
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to tumor necrosis factor
RNA phosphodiester bond hydrolysis
RNA phosphodiester bond hydrolysis, endonucleolytic
RNA phosphodiester bond hydrolysis, exonucleolytic
cellular response to virus
negative regulation of cytokine production involved in inflammatory response
positive regulation of execution phase of apoptosis
negative regulation of interleukin-6 secretion
positive regulation of p38MAPK cascade
negative regulation of interferon-gamma secretion
positive regulation of protein deubiquitination
negative regulation of production of miRNAs involved in gene silencing by miRNA
cellular response to sodium arsenite
negative regulation of tumor necrosis factor secretion
cellular response to phorbol 13-acetate 12-myristate
cellular response to ionomycin
cellular response to chemokine
positive regulation of reactive oxygen species metabolic process
positive regulation of miRNA catabolic process
