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ZFYVE9 Antibody (PA5-67946) in WB
Science advances 2021 -
Fig. 6. Smad3 is a GLRX substrate, and glutathionylation of Smad3 is indispensable for its transactivation of fibrogenic genes. ( A ) Gene expression in mouse HSCs infected with Ad-GLRX and treated with TGFbeta1 (4 ng/ml) for 24 hours. ( B ) Protein interactions were assessed by co-IP in LX2 cells transfected with HA-Smad2 or HA-Smad3, and His-GLRX plasmids. ( C ) Immunofluorescence assessment of Smad3 in m... View More
产品信息
PA5-67946
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from human ZFYVE9.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
affinity chromatography
保存液
PBS, pH 7.3, with 30% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2691844
产品详细信息
Predicted to react with Mouse samples.
靶标信息
Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: hSARA; MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchor; MADH-interacting protein; Mothers against decapentaplegic homolog-interacting protein; Novel serine protease; NSP; protein phosphatase 1, regulatory subunit 173; Receptor activation anchor; Smad anchor for receptor activation; Zinc finger FYVE domain-containing protein 9; zinc finger, FYVE domain containing 9
基因别名: E030027L17; MADHIP; NSP; PPP1R173; SARA; SMADIP; ZFYVE9
UniProt ID: (Human) O95405
Entrez Gene ID: (Human) 9372, (Mouse) 230597
