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Positive Samples: Rat lung; Cellular Location: Nucleus
Immunogen sequence: PDLSSLQAGS ACLAKHQDGL WHAARITDVD NGYYTVKFDS LLLREAVVEG DGILPPLRTE
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. [UniProt]
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: G patch domain-containing protein 6; Zinc finger and G patch domain-containing protein; Zinc finger CCCH domain-containing protein 9; zinc finger CCCH-type with G patch domain; Zinc finger CCCH-type with G patch domain-containing protein; zinc finger, CCCH-type with G patch domain; zinc finger, CCCH-type with G-patch domain
基因别名: GPATC6; GPATCH6; KIAA1847; RGD1310801; ZC3H9; ZC3HDC9; ZGPAT; ZIP
UniProt ID: (Human) Q8N5A5, (Rat) Q5PPF5
Entrez Gene ID: (Human) 84619, (Rat) 296478