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产品信息
PA5-68923
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the C terminal region of mouse ZHX2
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2692289
产品详细信息
This target displays homology in the following species: Cow: 86%; Dog: 86%; Horse: 79%; Human: 79%; Mouse: 100%; Pig: 93%; Rabbit: 86%; Rat: 100%
靶标信息
Zinc-fingers and homeobox (ZHX) proteins are transcription factors that interact with the activation domain of the A subunit of nuclear factor-Y (NF-YA). ZHX1-3 are ubiquitously expressed proteins expressed in various tissues. They act as transcriptional repressors and localize to the nucleus. The ZHX proteins contain two Cys(2)-His(2)-type zinc-finger motifs and five homeodomains (HDs). These domains allow the ZHX proteins to form homodimers, but they can also form heterodimers with each other. However, this dimerization is not required for repressor activity. Hypermethylation-mediated silencing of ZHX2 is an epigenetic event involved in hepatocellular carcinoma (HCC).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AFP regulator 1; alpha fetoprotein regulation 1, adult; Alpha-fetoprotein regulator 1; Regulator of AFP; Zinc finger and homeodomain protein 2; Zinc fingers and homeoboxes protein 2
基因别名: Afr-1; Afr1; mKIAA0854; Raf; Zhx2
UniProt ID: (Mouse) Q8C0C0
Entrez Gene ID: (Mouse) 387609
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
mRNA catabolic process
somatic stem cell population maintenance
negative regulation of neuron differentiation
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
