Invitrogen

ZIC1/ZIC2/ZIC3 Polyclonal Antibody

ZIC1/ZIC2/ZIC3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ZIC1/ZIC2/ZIC3 Antibody (PA5-99208) in IHC (P)

Immunohistochemistry analysis of paraffin-embedded ZIC1/ZIC2/ZIC3 in human brain tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with ZIC1/ZIC2/ZIC3 polyclonal antibody (Product # PA5-99208) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.

ZIC1/ZIC2/ZIC3 Antibody in Western Blot (WB)

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产品信息

PA5-99208

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:100-1:500

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human ZIC1(Accession Q15915), corresponding to amino acid residues G328-R378.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2818141

产品详细信息

Antibody detects endogenous levels of total ZIC1/2/3.

靶标信息

Zic1 encodes a zinc finger protein expressed in the developing or matured central nervous system in a highly restricted manner. Zic is expressed in granule cells that make synaptic contact with Purkinje cells. Zic1 is a gene critical to cerebellar pattern formation. The expression of Zic genes is first detected at gastrulation and at neurulation, becoming restricted to the dorsal neural ectoderm and the dorsal paraxial mesoderm. The Zic1 gene has been mapped to chromosome 9 in mouse. The 5' flanking region of the Zic1 gene contains a region-specific enhancer determined to be essential in in-vivo and in-vitro deletion analysis. The temporal profile of mRNA expression differs for each of the Zic gene products. The Drosophila odd-paired gene is highly homologous to the Zic gene family. Zic2 and Zic3 are highly similar genes. Zic2 is essential for the formation of the brain and Zic-3 is important for right and left axis formation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: GENA 29; heterotaxy 1; kumba; odd-paired homolog; Zic family member 1 (odd-paired homolog, Drosophila); Zic family member 2 (odd-paired homolog, Drosophila); Zic family member 3 (odd-paired homolog, Drosophila); Zinc finger protein 201; Zinc finger protein 203; Zinc finger protein of the cerebellum 1; Zinc finger protein of the cerebellum 2; Zinc finger protein of the cerebellum 3; Zinc finger protein ZIC 1; Zinc finger protein ZIC 2; Zinc finger protein ZIC 3

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基因别名: Bn; CRS6; HPE5; HTX; HTX1; Ka; Ku; VACTERLX; ZIC; ZIC1; ZIC2; ZIC3; ZNF201; ZNF203