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产品信息
MA5-22840
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
1E2
抗原
ZNF598 (NP_835461, 28 a.a. ~ 126 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2607000
产品详细信息
Peptide Sequence: SCVLCCGDLE ATALGRCDHP VCYRCSTKMR VLCEQRYCAV CREELRQVVF GKKLPAFATI PIHQLQHEKK YDIYFADGKV YALYRQLLQH ECPRCPELP
靶标信息
ZNF598 (E3 ubiquitin-protein ligase ZNF598) plays a key role in the ribosome quality control (RQC). RQC is a pathway that takes place when a ribosome has stalled during translation. It is required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40A ribosomal protein RPS10/eS10 and RPS3/uS3. Stalling precludes synthesis of a long poly-lysine tail and initiated the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C6orf149; E3 ubiquitin-protein ligase ZNF598; FLJ00086; ISD11; Zinc finger protein 598
基因别名: ZNF598
UniProt ID: (Human) Q86UK7
Entrez Gene ID: (Human) 90850
