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alpha-1b Adrenergic Receptor Antibody (PA5-32660) in IHC (P)
Immunohistochemistry analysis of alpha-1b Adrenergic Receptor in human smooth muscle cells. Samples were incubated with alpha-1b Adrenergic Receptor polyclonal antibody (Product # PA5-32660). Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
产品信息
PA5-32660
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 20 amino acid peptide from C-terminal cytoplasmic domain of human ADRA1B.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2550123
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey, Marmoset (95%); Mouse, Hamster, Elephant (85%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
靶标信息
The alpha-1b adrenoceptor is an Adrenergic Receptor that causes contraction of smooth muscle cells and thereby controls vascular tone, blood pressure, and accelerates the development of atherosclerosis. Decreased alpha-1b adrenoceptor is associated with benign prostatic hyperplasia (BPH). This adrenergic receptor also acts as a proto-oncogene when transfected into cell lines where constitutive activation of the receptor induces neoplastic transformation. The alpha-1b adrenoceptor has been documented in adrenal, aorta, blood, various brain regions, eye, heart, kidney, liver, prostate, spinal cord, and spleen. ESTs have been isolated from kidney (normal and cancer) and lung carcinoma libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADA1B; adrenergic, alpha-1B-, receptor; Alpha-1B adrenergic receptor; Alpha-1B adrenoceptor; Alpha-1B adrenoreceptor; alpha-1B-adrenergic receptor
基因别名: ADRA1; ADRA1B; ALPHA1BAR
UniProt ID: (Human) P35368
Entrez Gene ID: (Human) 147
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
multicellular organism development
cell proliferation
intracellular signal transduction
glucose homeostasis
positive regulation of MAPK cascade
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
regulation of cardiac muscle contraction
adenylate cyclase-activating adrenergic receptor signaling pathway
