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alpha-2a Adrenergic Receptor Antibody (PA5-18475) in ICC/IF
Immunocytochemical analysis of alpha 2a Adrenergic Receptor in MCF7 cells using a alpha 2a Adrenergic Receptor polyclonal antibody (Product #PA5-18475). MCF7 cells were permeabilized with 0.15% Triton. Cells were incubated with 10 µg/mL of primary antibody for one hour followed by an Alexa Fluor 488 secondary antibody at a concentration of 2 µg/mL. Membrane staining can be seen as shown above. The nuclear s... View More
产品信息
PA5-18475
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (TERRPNGLGPERS) corresponding to the internal amino acids of ADRA2A (aa 261-274).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10983912
产品详细信息
This antibody is predicted to react with canine, human and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
靶标信息
Alpha-2-adrenergic receptors (ADRA2A) are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. ADRA2A mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G protein. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adrenergic, alpha-2A-, receptor; Alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type; Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; alpha-2AAR subtype C10; OTTHUMP00000058849
基因别名: ADRA2; ADRA2A; ADRA2R; ADRAR; ALPHA2AAR; ZNF32
UniProt ID: (Human) P08913
Entrez Gene ID: (Human) 150
alpha2-adrenergic receptor activity
protein binding
protein kinase binding
alpha-1B adrenergic receptor binding
alpha-2C adrenergic receptor binding
thioesterase binding
heterotrimeric G-protein binding
protein homodimerization activity
protein heterodimerization activity
epinephrine binding
norepinephrine binding
G-protein coupled receptor
positive regulation of cytokine production
acute inflammatory response
DNA replication
movement of cell or subcellular component
signal transduction
G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
Ras protein signal transduction
Rho protein signal transduction
female pregnancy
positive regulation of cell proliferation
negative regulation of norepinephrine secretion
regulation of vasoconstriction
actin cytoskeleton organization
platelet activation
positive regulation of cell migration
negative regulation of cAMP biosynthetic process
activation of protein kinase activity
activation of protein kinase B activity
negative regulation of epinephrine secretion
cellular response to hormone stimulus
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
glucose homeostasis
positive regulation of potassium ion transport
positive regulation of MAP kinase activity
positive regulation of epidermal growth factor-activated receptor activity
positive regulation of vasodilation
negative regulation of calcium ion-dependent exocytosis
negative regulation of insulin secretion
regulation of insulin secretion
intestinal absorption
thermoception
negative regulation of lipid catabolic process
positive regulation of membrane protein ectodomain proteolysis
negative regulation of calcium ion transport
negative regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of uterine smooth muscle contraction
negative regulation of adrenergic receptor signaling pathway
adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
phospholipase C-activating adrenergic receptor signaling pathway
activation of MAPK activity by adrenergic receptor signaling pathway
positive regulation of wound healing
negative regulation of calcium ion transmembrane transporter activity
