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Invitrogen
alpha-2b Adrenergic Receptor Monoclonal Antibody (5G10)
产品信息
MA1-12721
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
5G10
抗原
Synthetic peptide corresponding to the third intracellular loop of rat alpha 2b adrenergic receptor.
偶联物
形式
Liquid
浓度
0.8 mg/mL
纯化类型
Protein A/G
保存液
PBS
内含物
0.08% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2225066
产品详细信息
A suggested positive control for this product is MDCK cells transfected with rat alpha2B adrenergic receptors.
靶标信息
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADA2B; Adrenergic alpha2B- receptor class III; adrenergic receptor, alpha 2b; adrenergic, alpha-2B-, receptor; Adrenergic, alpha2B-, receptor class III; Alpha-2B adrenergic receptor; Alpha-2B adrenoceptor; Alpha-2B adrenoreceptor; alpha-2BAR; subtype alpha2-C2
基因别名: [a]2B; Adra-2b; Adra2b; alpha2-C2; alpha2B
UniProt ID: (Mouse) P30545, (Rat) P19328
Entrez Gene ID: (Mouse) 11552, (Rat) 24174
MAPK cascade
activation of MAPK activity
angiogenesis
regulation of vascular smooth muscle contraction
G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
cell-cell signaling
female pregnancy
negative regulation of norepinephrine secretion
activation of protein kinase B activity
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
positive regulation of neuron differentiation
positive regulation of blood pressure
negative regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of uterine smooth muscle contraction
adrenergic receptor signaling pathway
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
activation of MAPK activity by adrenergic receptor signaling pathway
platelet activation
