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alpha-2c Adrenergic Receptor Antibody (PA5-114828) in ICC/IF
Immunocytochemistry analysis of alpha-2c Adrenergic Receptor in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-114828) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 8... View More
产品信息
PA5-114828
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ADRA2C(Accession P18825), corresponding to amino acid residues S349-F399.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899464
产品详细信息
Antibody detects endogenous levels of total Adrenergic Receptor alpha -2C.
靶标信息
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Adra 2c; Adrenergic alpha2C- receptor class I; adrenergic receptor, alpha 2c; adrenergic, alpha-2C-, receptor; Adrenergic, alpha2C-, receptor class I; Alpha 2CAR; Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenergic receptor; Alpha-2C adrenoceptor; Alpha-2C adrenoreceptor; alpha-2C-adrenergic receptor; Alpha-2C-AR; alpha-2CAR; alpha2 AR C4; alpha2 C4; alpha2-AR-C4; subtype alpha2-C4
基因别名: [a]2C; Adra-2c; ADRA2C; ADRA2L2; ADRA2RL2; ADRARL2; alpha2-C4; alpha2C; ALPHA2CAR
UniProt ID: (Human) P18825, (Mouse) Q01337, (Rat) P22086
Entrez Gene ID: (Human) 152, (Mouse) 11553, (Rat) 24175
G-protein coupled receptor signaling pathway
cell-cell signaling
female pregnancy
negative regulation of norepinephrine secretion
platelet activation
activation of protein kinase B activity
negative regulation of epinephrine secretion
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
positive regulation of neuron differentiation
positive regulation of vasoconstriction
regulation of insulin secretion
regulation of sensory perception of pain
negative regulation of uterine smooth muscle contraction
adenylate cyclase-activating adrenergic receptor signaling pathway
activation of MAPK activity by adrenergic receptor signaling pathway
regulation of smooth muscle contraction
signal transduction
negative regulation of adenylate cyclase activity
regulation of vasoconstriction
negative regulation of insulin secretion involved in cellular response to glucose stimulus
adrenergic receptor signaling pathway
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
