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beta-2 Adrenergic Receptor Antibody (PA5-86483) in IHC (P)
Immunohistochemical analysis of beta-2 Adrenergic Receptor in paraffin-embedded human tonsil carcinoma tissue showing cytoplasmic/nucleus staining and negative control (right). Sample was incubated with polyclonal beta-2 Adrenergic Receptor antibody (Product # PA5-86483) using a 1:50 dilution, and followed by goat anti-rabbit IgG-biotin and avidin-peroxidase secondary antibodies.
产品信息
PA5-86483
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, corresponding to amino acids 351-400 of Human AR-beta2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2803261
产品详细信息
Multiple bands are observed at 47 kDa,68 kDa (glycosylated), and 95 kDa(Dimer).
Purity is > 95% by SDS-PAGE.
靶标信息
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.
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生物信息学
蛋白别名: adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; adrenoceptor beta 2, surface; AR beta2; Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor; beta2-Adrenoreceptor; catecholamine receptor; HGNC:286
基因别名: ADRB2; ADRB2R; ADRBR; B2AR; BAR; BETA2AR
UniProt ID: (Human) P07550
Entrez Gene ID: (Human) 154
G-protein alpha-subunit binding
beta2-adrenergic receptor activity
protein binding
drug binding
adenylate cyclase binding
potassium channel regulator activity
B2 bradykinin receptor binding
protein complex binding
dopamine binding
ionotropic glutamate receptor binding
protein homodimerization activity
epinephrine binding
norepinephrine binding
G-protein coupled receptor
diet induced thermogenesis
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
diaphragm contraction
positive regulation of the force of heart contraction by epinephrine
receptor-mediated endocytosis
cell surface receptor signaling pathway
activation of transmembrane receptor protein tyrosine kinase activity
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
cell-cell signaling
female pregnancy
aging
positive regulation of cell proliferation
associative learning
endosome to lysosome transport
response to cold
positive regulation of sodium ion transport
negative regulation of angiogenesis
negative regulation of ossification
positive regulation of bone mineralization
positive regulation of protein ubiquitination
heat generation
response to progesterone
positive regulation of ATPase activity
response to testosterone
synaptic transmission, glutamatergic
negative regulation of urine volume
negative regulation of multicellular organism growth
wound healing
positive regulation of apoptotic process
positive regulation of potassium ion transport
positive regulation of MAPK cascade
response to estrogen
estrous cycle
bone resorption
positive regulation of vasodilation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of smooth muscle contraction
positive regulation of skeletal muscle tissue growth
negative regulation of inflammatory response
brown fat cell differentiation
regulation of calcium ion transport
regulation of sensory perception of pain
excitatory postsynaptic potential
cellular response to hypoxia
response to dexamethasone
response to monoamine
adenylate cyclase-activating adrenergic receptor signaling pathway
negative regulation of platelet aggregation
liver regeneration
positive regulation of autophagosome maturation
positive regulation of lipophagy
positive regulation of mitophagy in response to mitochondrial depolarization
