Invitrogen

beta-Arrestin 2 Polyclonal Antibody

高级验证

This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.

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7 篇参考文献
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产品信息

PA1-732

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:2,000
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免疫组化 (IHC)

-
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免疫细胞化学 (ICC/IF)

2 µg/mL
-

免疫沉淀 (IP)

-
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产品规格

种属反应

Bovine, Human, Mouse, Rat

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to residues C D(384) D I V F E D F A R L R L K(397) of human beta-arrestin 2.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 1mg/mL BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2060256

产品详细信息

PA1-732 detects beta-Arrestin 2 in rat, human and bovine samples.

PA1-732 has been successfully used in Western blot procedures. By Western blot, this antibody detects ~49 kDa and ~47 kDa proteins representing pan Arrestin in rat and bovine retina as well as rat brain samples.

The PA1-732 immunogen is a synthetic peptide corresponding to residues C D(384) D I V F E D F A R L R L K(397) of human beta-arrestin 2. This peptide (Cat. # PEP-281) is available for use in neutralization and control experiments.

靶标信息

Beta-arrestin-2, or ARRB2, is an adaptor protein belonging to the arrestin family with an N- arrestin domain and a C- arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta2-adrenergic receptor (beta2AR) function by enhancing beta2AR mediated nuclear translocation of ERK. ARRB2 binds to phosphorylated beta2ARs, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: arrestin 3; Arrestin beta-2; arrestin, beta 2; arrestin-3; beta arr2; beta-arrestin 2 long isoform; beta-arrestin 2 short isoform; Beta-arrestin-2; Non-visual arrestin-3

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基因别名: AI326910; ARB2; ARR2; ARRB2; AW122872; BARR2; BARRES

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UniProt ID: (Human) P32121, (Mouse) Q91YI4, (Rat) P29067

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Entrez Gene ID: (Bovine) 281638, (Human) 409, (Mouse) 216869, (Rat) 25388

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功能
inositol hexakisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding phosphatidylinositol binding G-protein coupled receptor binding receptor binding protein binding enzyme binding protein domain specific binding ubiquitin protein ligase binding alpha-1A adrenergic receptor binding alpha-1B adrenergic receptor binding angiotensin receptor binding type 1 angiotensin receptor binding D1 dopamine receptor binding follicle-stimulating hormone receptor binding type 2A serotonin receptor binding platelet activating factor receptor binding protein complex binding protein complex scaffold protein kinase B binding mitogen-activated protein kinase binding 14-3-3 protein binding clathrin binding scaffold/adaptor protein
参与通路
desensitization of G-protein coupled receptor protein signaling pathway G-protein coupled receptor internalization positive regulation of receptor internalization signal transduction protein transport receptor internalization desensitization of G-protein coupled receptor protein signaling pathway by arrestin transcription from RNA polymerase II promoter transforming growth factor beta receptor signaling pathway dopamine receptor signaling pathway brain development adult walking behavior protein ubiquitination platelet activation negative regulation of protein ubiquitination positive regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity positive regulation of synaptic transmission, dopaminergic negative regulation of interleukin-1 beta production negative regulation of interleukin-12 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of peptidyl-serine phosphorylation negative regulation of toll-like receptor signaling pathway negative regulation of GTPase activity negative regulation of smooth muscle cell apoptotic process follicle-stimulating hormone signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of natural killer cell mediated cytotoxicity positive regulation of peptidyl-tyrosine phosphorylation detection of temperature stimulus involved in sensory perception of pain positive regulation of protein kinase B signaling negative regulation of protein kinase B signaling positive regulation of calcium ion transport Wnt signaling pathway, planar cell polarity pathway cell chemotaxis regulation of androgen receptor signaling pathway positive regulation of ERK1 and ERK2 cascade negative regulation of release of cytochrome c from mitochondria chemical synaptic transmission, postsynaptic positive regulation of DNA biosynthetic process regulation of protein phosphorylation positive regulation of protein phosphorylation transport endocytosis G-protein coupled receptor signaling pathway regulation of G-protein coupled receptor protein signaling pathway negative regulation of signal transduction regulation of cAMP biosynthetic process regulation of cAMP catabolic process
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