Invitrogen

betatrophin Polyclonal Antibody

betatrophin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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betatrophin Antibody (PA5-38043) in IHC (P)

Immunohistochemistry of Betatrophin in mouse liver tissue with betatrophin Polyclonal Antibody (Product # PA5-38043) at 5 µg/mL.

betatrophin Antibody in Western Blot (WB)

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产品信息

PA5-38043

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-2 µg/mL

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

5 µg/mL

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

16 amino acid peptide near the amino terminus of human Betatrophin

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2554647

产品详细信息

A recommended positive control is rat liver tissue lysate.

At least three isoforms of Betatrophin are known to exist; this antibody will detect the two largest isoforms.

靶标信息

The Betatrophin protein, also known as the hepatocellular carcinoma-associated protein TD26, is an adipocyte- and liver-enriched insulin targeted gene that is thought to play a role in lipid metabolism be regulating serum triglyceride levels. Betatrophin is closely related to the angiopoietin-like (ANGPTL) protein family. Betatrophin mRNA increases in the cold environment and after treatment with a high-fat diet, while its mRNA levels decrease in response to fasting, suggesting that it may play a role in mediating thermogenesis and energy homeostasis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis.

Nature communications

Li DP,Huang L,Kan RR,Meng XY,Wang SY,Zou HJ,Guo YM,Luo PQ,Pan LM,Xiang YX,Mao BB,Xie YY,Wang ZH,Yang M,He R,Yang Y,Liu ZL,Xie JH,Ma DL,Zhang BP,Shao SY,Chen X,Xu SM,He WT,Li WJ,Chen Y,Yu XF

PA5-38043 was used in Immunohistochemistry-immunofluorescence to demonstrate that PirB/LILRB2 regulates the migration of macrophages during NASH by binding with its ligand angiopoietin-like protein 8.

Sat Jul 22 00:00:00 EDT 2023

Increased expression level of ANGPTL8 in white adipose tissue under acute and chronic cold treatment.

Lipids in health and disease

Arefanian H,Al-Khairi I,Khalaf NA,Cherian P,Kavalakatt S,Madhu D,Mathur A,Qaddoumi MG,Al-Mulla F,Abubaker J,Abu-Farha M

PA5-38043 was used in Western Blot to evaluated the level of angiopoietin-like proteins 3, 4, and 8 in the liver, brown adipose tissue, and subcutaneous white adipose tissue of mice maintained under acute and chronic cold conditions.

Sun Sep 26 00:00:00 EDT 2021

Increased expression level of ANGPTL8 in white adipose tissue under acute and chronic cold treatment.

Lipids in health and disease

Arefanian H,Al-Khairi I,Khalaf NA,Cherian P,Kavalakatt S,Madhu D,Mathur A,Qaddoumi MG,Al-Mulla F,Abubaker J,Abu-Farha M

Sun Sep 26 00:00:00 EDT 2021

Effects of vitamin D on apoptosis and betatrophin in the kidney tissue of experimental diabetic rats.

Acta bio-medica : Atenei Parmensis

Demircan S,Onalan E,Kuloğlu T,Aydın S,Yalçın MH,Gözel N,Dönder E

PA5-38043 was used in Immunohistochemistry to investigate the effects of vitD on betatrophin and apoptosis in rat kidney tissue using an experimental diabetes model.

Mon Sep 21 00:00:00 EDT 2020

Angptl8 mediates food-driven resetting of hepatic circadian clock in mice.

Nature communications

Chen S,Feng M,Zhang S,Dong Z,Wang Y,Zhang W,Liu C

PA5-38043 was used in Western Blotting to study the role of Angptl8 in the circadian rhythm of the liver in response to food.

Tue Aug 06 00:00:00 EDT 2019

生物信息学

蛋白别名: angiopoietin-like 8; Angiopoietin-like protein 8; Betatrophin; betatrophin variant 1; betatrophin variant 2; hepatocellular carcinoma-associated gene TD26; hepatocellular carcinoma-associated protein TD26; hepatocellular carcinoma-associated protein TD26 homolog; Lipasin; Refeeding-induced fat and liver protein

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基因别名: ANGPTL8; C19orf80; EG624219; Gm6484; PRO1185; PVPA599; RIFL; TD26; UNQ599/PRO1185

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UniProt ID: (Human) Q6UXH0, (Mouse) Q8R1L8

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Entrez Gene ID: (Human) 55908, (Mouse) 624219, (Rat) 100361444

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功能

hormone activity protein binding

参与通路