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brat Antibody (PA5-144542) in WB
Western blot analysis of brat in recombinant protein using a dilution of 1:1,000. Samples were incubated with brat polyclonal antibody (Product # PA5-144542). Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 31 kDa. Observed band size: 31 kDa.
产品信息
PA5-144542
产品规格
种属反应
Fruit fly
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Drosophila melanogaster (Fruit fly) brat protein (294-487aa)
偶联物
形式
Liquid
浓度
5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% Proclin 300
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_3092389
靶标信息
A NHL-domain family protein that functions a translational repressor to inhibit cell proliferation (PubMed:11274060). Plays a central role in translation repression of hb mRNA by being recruited by nanos (nos) and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR (PubMed:11274060). Probably recruited by other proteins to repress translation of other mRNAs in other tissues (PubMed:11274060). Involved in the regulation of ribosomal RNA synthesis and cell growth (PubMed:11807032). Participates in abdominal segmentation and imaginal disk development (PubMed:11274060). During neuroblast division, segregates asymmetrically and inhibits self-renewal of one of the two daughter cells (PubMed:16564014). Together with the asymmetrically segregating transcription factor prospero ensures that the daughter cell will stop growing, exit the cell cycle, and differentiate into neurons possibly by modulating the function of dm in ganglion mother cells (GMC) (PubMed:11807032, PubMed:16564014). Restricts developmental potential of type II intermediary neuronal progenitor (INP) cells playing a role in proliferation and maturation of the neuroblasts (PubMed:24550111, PubMed:14561773, PubMed:22143802, PubMed:18342578).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Brain tumor protein; Brain tumor protein brat CG10719; brain tumour; brat-PA; brat-PB; brat-PC; brat-PE; brat-PF; CG10719-PA; CG10719-PB; CG10719-PC; CG10719-PE; CG10719-PF
基因别名: anon-37CDa; BRAT; Cf; CG10719; Dmel\CG10719; Dmel_CG10719; E60; fs(2)ltoPM43; l(2)37Cf; l(2)brat; l(2)E60; lincRNA.S1565
UniProt ID: (Fruit fly) Q8MQJ9
Entrez Gene ID: (Fruit fly) 35197
regulation of translation
neuroblast fate determination
ganglion mother cell fate determination
neuroblast proliferation
negative regulation of neuroblast proliferation
axon guidance
ventral cord development
brain development
negative regulation of cell proliferation
asymmetric cell division
regulation of synaptic growth at neuromuscular junction
rRNA transcription
negative regulation of gene expression
neuroblast differentiation
neuroblast development
negative regulation of translation
neuron differentiation
segmentation
oogenesis
regulation of neurogenesis
asymmetric neuroblast division resulting in ganglion mother cell formation
regulation of synaptic vesicle endocytosis
regulation of neuroblast proliferation
