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产品信息
PA1-28083
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Human,
Mouse,
Rat
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 14-residue synthetic peptide corresponding to residues 4-17 of human PKG 1 beta. Tryptophan was substituted for tyrosine at position 9. A terminal cysteine was added and the peptide conjugated to KLH.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_1959760
产品详细信息
A suggested positive control is HeLa cell lysate
靶标信息
PRKG1 is a cGMP-dependent serine/threonine kinase which has an important role in the relaxation of vascular smooth muscle and the inhibition of platelet aggregation. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: cGK 1; CGK 1 alpha; cGK 1 beta; cGK cGK cGKI; cGK cGK1; cGK1; cGKI; cGKI-alpha; cGMP dependent protein kinase type 1; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase 1, alpha isozyme; cGMP-dependent protein kinase 1, beta isozyme; cGMP-dependent protein kinase I; OTTHUMP00000019618; protein kinase, cGMP-dependent, regulatory, type I, beta; protein kinase, cGMP-dependent, type I; RP11-346D6.1; unnamed protein product
基因别名: AAT8; AW125416; cGK; cGK 1; cGK1; CGKI; cGKI-alpha; cGKI-BETA; Gm19690; PKG; Pkgi; PRKG1; PRKG1B; PRKGR1A; PRKGR1B
UniProt ID: (Bovine) P00516, (Human) Q5JP05, (Mouse) P0C605
Entrez Gene ID: (Bovine) 282004, (Human) 5592, (Mouse) 19091, (Rat) 54286
cGMP-dependent protein kinase activity
calcium channel regulator activity
ATP binding
cGMP binding
protein serine/threonine kinase activity
protein binding
nucleotide binding
catalytic activity
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein homodimerization activity
mitogen-activated protein kinase p38 binding
non-receptor serine/threonine protein kinase
neuron migration
protein phosphorylation
dendrite development
cGMP-mediated signaling
forebrain development
regulation of GTPase activity
relaxation of vascular smooth muscle
negative regulation of platelet aggregation
negative regulation of vascular smooth muscle cell proliferation
negative regulation of vascular associated smooth muscle cell migration
signal transduction
actin cytoskeleton organization
mitophagy in response to mitochondrial depolarization
positive regulation of cytosolic calcium ion concentration
metabolic process
negative regulation of inositol phosphate biosynthetic process
negative regulation of glutamate secretion
negative regulation of smooth muscle cell migration
phosphorylation
positive regulation of circadian rhythm
negative regulation of heart contraction
positive regulation of vasodilation
negative regulation of smooth muscle contraction
cell growth involved in cardiac muscle cell development
positive regulation of large conductance calcium-activated potassium channel activity
regulation of testosterone biosynthetic process
spermatid development
brain development
heart development
cerebellum development
