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产品信息
PA5-27325
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 1 and 686 of Human cGK1 beta
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2544801
产品详细信息
Recommended positive controls: NIH-3T3, JC.
Predicted reactivity: Mouse (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
PRKG1 is a cGMP-dependent serine/threonine kinase which has an important role in the relaxation of vascular smooth muscle and the inhibition of platelet aggregation. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: cGK 1; cGK cGK cGKI; cGK cGK1; cGK1; cGKI; cGMP dependent protein kinase type 1; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase I; OTTHUMP00000019618; protein kinase, cGMP-dependent, regulatory, type I, beta; protein kinase, cGMP-dependent, type I; RP11-346D6.1
基因别名: AAT8; AW125416; cGK; cGK 1; cGK1; CGKI; cGKI-alpha; cGKI-BETA; Gm19690; PKG; Pkgi; PRKG1; PRKG1B; PRKGR1A; PRKGR1B
UniProt ID: (Human) Q5JP05, (Mouse) P0C605
Entrez Gene ID: (Human) 5592, (Mouse) 19091, (Rat) 54286
protein serine/threonine kinase activity
cGMP-dependent protein kinase activity
calcium channel regulator activity
protein binding
ATP binding
cGMP binding
nucleotide binding
catalytic activity
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein homodimerization activity
mitogen-activated protein kinase p38 binding
non-receptor serine/threonine protein kinase
neuron migration
protein phosphorylation
signal transduction
dendrite development
cGMP-mediated signaling
actin cytoskeleton organization
forebrain development
regulation of GTPase activity
relaxation of vascular smooth muscle
negative regulation of platelet aggregation
mitophagy in response to mitochondrial depolarization
positive regulation of cytosolic calcium ion concentration
metabolic process
negative regulation of inositol phosphate biosynthetic process
negative regulation of glutamate secretion
negative regulation of smooth muscle cell migration
phosphorylation
positive regulation of circadian rhythm
negative regulation of heart contraction
positive regulation of vasodilation
negative regulation of smooth muscle contraction
cell growth involved in cardiac muscle cell development
positive regulation of large conductance calcium-activated potassium channel activity
regulation of testosterone biosynthetic process
spermatid development
brain development
heart development
cerebellum development
