Invitrogen

eNOS Polyclonal Antibody

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4 篇参考文献
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产品信息

PA5-16887

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:50-1:500
-

免疫组化 (IHC)

-
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免疫组化（石蜡） (IHC (P))

1:70
-

免疫细胞化学 (ICC/IF)

2 µg/mL
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产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide derived from C-ternimal of human eNOS
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.081 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.6, with 1% BSA

内含物

0.1% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_10984948

产品详细信息

PA5-16887 targets eNOS in immunohistochemistry (paraffin) applications and shows reactivity with Bovine, Canine, Human, mouse, Porcine, and Rat samples. Suggested positive control is capillary endothelium and regenerative endothelium.

The PA5-16887 immunogen is a synthetic peptide derived from C-ternimal of human eNOS.

靶标信息

Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) and endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. All NOS isoforms contain calmodulin, nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), and flavin mononucleotide (FMN) binding domains.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: cNOS; Constitutive NOS; e-NOS; EC-NOS; Endothelial NOS; Nitric oxide synthase 3; nitric oxide synthase 3 (endothelial cell); nitric oxide synthase 3 transcript variant eNOS-delta20; nitric oxide synthase 3 transcript variant eNOS-delta20-21; nitric oxide synthase 3 transcript variant eNOS-delta21; Nitric oxide synthase, endothelial; NOS type III; NOSIII; OTTHUMP00000213183

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基因别名: ECNOS; eNOS; NOS3

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UniProt ID: (Human) P29474

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Entrez Gene ID: (Human) 4846

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功能
actin monomer binding nitric-oxide synthase activity iron ion binding protein binding calmodulin binding FMN binding heme binding tetrahydrobiopterin binding arginine binding cadmium ion binding flavin adenine dinucleotide binding NADP binding scaffold protein binding oxidoreductase protein modifying enzyme
参与通路
angiogenesis ovulation from ovarian follicle in utero embryonic development blood vessel remodeling regulation of sodium ion transport regulation of the force of heart contraction by chemical signal regulation of systemic arterial blood pressure by endothelin arginine catabolic process nitric oxide biosynthetic process mitochondrion organization nitric oxide mediated signal transduction regulation of blood pressure negative regulation of cell proliferation response to heat negative regulation of platelet activation negative regulation of muscle hyperplasia smooth muscle hyperplasia removal of superoxide radicals lung development positive regulation of guanylate cyclase activity lipopolysaccharide-mediated signaling pathway response to fluid shear stress negative regulation of potassium ion transport endothelial cell migration cell redox homeostasis positive regulation of angiogenesis negative regulation of blood pressure positive regulation of vasodilation regulation of blood vessel size regulation of nitric-oxide synthase activity negative regulation of hydrolase activity negative regulation of calcium ion transport oxidation-reduction process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
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