Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 3
hnRNP D Antibody (PA5-27533) in ICC/IF
hnRNP D Polyclonal Antibody detects AUF1 protein at cytoplasm and nucleus by immunofluorescent analysis. Sample: Hep G2 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: AUF1 protein stained by hnRNP D Polyclonal Antibody (Product # PA5-27533) diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 µm.
产品信息
PA5-27533
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 18 and 225 of Human AUF1
偶联物
形式
Liquid
浓度
0.69 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545009
产品详细信息
Recommended positive controls: A431.
Predicted reactivity: Mouse (98%), Rat (98%), Xenopus laevis (82%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: ARE-binding protein AUFI, type A; AU-rich element RNA binding protein 1, 37kDa; AU-rich element RNA-binding protein 1; heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa); Heterogeneous nuclear ribonucleoprotein D0; hnRNP D0
基因别名: AUF1; AUF1A; HNRNPD; hnRNPD0; HNRPD; P37
UniProt ID: (Human) Q14103
Entrez Gene ID: (Human) 3184
mRNA splicing, via spliceosome
liver development
transcription, DNA-templated
regulation of transcription, DNA-templated
RNA processing
RNA catabolic process
gene expression
response to fluoxetine
cerebellum development
regulation of circadian rhythm
regulation of mRNA stability
positive regulation of translation
positive regulation of transcription, DNA-templated
mRNA stabilization
response to calcium ion
response to electrical stimulus
3'-UTR-mediated mRNA destabilization
cellular response to amino acid stimulus
cellular response to estradiol stimulus
cellular response to nitric oxide
circadian regulation of translation
response to rapamycin
response to sodium phosphate
cellular response to putrescine
hepatocyte dedifferentiation
