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hnRNP M1-M4 Antibody (PA5-99438) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded hnRNP M1-M4 in human kidney tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with hnRNP M1-M4 polyclonal antibody (Product # PA5-99438) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-99438
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human HNRNPM(Accession P52272), corresponding to amino acid residues G23-A73.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2818371
产品详细信息
Antibody detects endogenous levels of total hnRNP M.
靶标信息
Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear ribonucleoproteins (hnRNPs), play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA-binding proteins with greatest similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64kDa subunit of cleavage stimulation factor, which is involved in 3'-end maturation of pre-mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CEA receptor; Heterogeneous nuclear ribonucleoprotein M; heterogenous nuclear ribonucleoprotein M4; hnRNA-binding protein M4; hnRNP M; HNRNP3; HNRNPM3; M4 protein; N-acetylglucosamine receptor 1
基因别名: 2610023M21Rik; AA409009; CEAR; hnRNP M; HNRNPM; HNRNPM4; HNRPM; HNRPM4; HTGR1; mKIAA4193; NAGR1
UniProt ID: (Human) P52272, (Rat) Q62826, (Mouse) Q9D0E1
Entrez Gene ID: (Human) 4670, (Rat) 116655, (Mouse) 76936
alternative mRNA splicing, via spliceosome
mRNA splicing, via spliceosome
fibroblast growth factor receptor signaling pathway
gene expression
cellular response to lipopolysaccharide
positive regulation of protein localization to nucleus
positive regulation of protein import
cellular response to carcinoembryonic antigen
mRNA processing
RNA splicing
