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产品信息
PA5-81560
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to the center region of the Mouse GRM1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2788760
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Mouse GRM1.
靶标信息
Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G protein coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member A; glutamate receptor; GRM1A; Metabotropic glutamate receptor 1; mGluR1; mGluR1a
基因别名: 4930455H15Rik; ENSMUSG00000075319; Gm10828; Gprc1a; Grm1; Mglur1; nmf373; rcw; wobl
UniProt ID: (Mouse) P97772
Entrez Gene ID: (Mouse) 14816
activation of MAPKK activity
activation of MAPK activity
signal transduction
G-protein coupled receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
locomotory behavior
sensory perception of pain
calcium-mediated signaling
dimeric G-protein coupled receptor signaling pathway
regulation of MAPK cascade
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
regulation of sensory perception of pain
regulation of synaptic transmission, glutamatergic
cellular response to electrical stimulus
