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mGluR1/mGluR5 Antibody (PA1-4663) in WB
Western blot of mGluR1/mGluR5 in HEK 293 cells (10 µg). Using a mGluR1/mGluR5 polyclonal antibody (Product # PA1-4663) it recognizes both mGluR5 (lane 1) and mGluR1a (lane 2), showing specific immunolabeling of a band at ~125 kDa corresponding to the monomer and a ~250 kDa band corresponding to the dimers for both receptors.
产品信息
PA1-4663
产品规格
种属反应
Mouse,
Rat
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the C-terminal region of rat GRM5 conjugated to KLH
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2115762
产品详细信息
This antibody is predicted to react with human and mouse based on 100% sequence homology.
This antibody is specific for the ~125 kDa monomer and the ~250 kDa dimmers of mGluR5 and mGluR1 in Western blots of rat brain extracts. Immunolabeling blocked by preadsorption of antibody with the peptide used to generate the antibody.
靶标信息
may play a role in synaptic transmission; may interact with mGluR1, another group I metabotropic glutamate receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: G protein coupled receptor family C group 1 member A; G protein coupled receptor, family C, group 1, member A; G protein coupled receptor, family C, group 1, member E; G protein-coupled receptor GRM5; G protein-coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member E; glutamate receptor; metabotropic glutamate receptor (mGluR5); Metabotropic glutamate receptor 1; Metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; metabotropic glutamate receptor subtype 5b; metabotropic glutamate receptor type 5; mGluR1; mGluR5; mGlurR1a
基因别名: 4930455H15Rik; 6430542K11Rik; AI850523; ENSMUSG00000075319; Glu5R; Gm10828; Gprc1a; Gprc1e; Grm1; Grm5; Mglur1; Mglur5; mGluR5b; nmf373; rcw; wobl
UniProt ID: (Mouse) P97772, (Rat) P23385, (Rat) P31424, (Mouse) Q3UVX5
Entrez Gene ID: (Mouse) 14816, (Rat) 24414, (Rat) 24418, (Mouse) 108071
PLC activating G-protein coupled glutamate receptor activity
signal transducer activity
G-protein coupled receptor activity
protein binding
glutamate receptor activity
estrogen receptor binding
identical protein binding
calmodulin binding
PDZ domain binding
A2A adenosine receptor binding
G-protein coupled receptor
activation of MAPKK activity
activation of MAPK activity
signal transduction
G-protein coupled receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
locomotory behavior
sensory perception of pain
calcium-mediated signaling
dimeric G-protein coupled receptor signaling pathway
regulation of MAPK cascade
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
regulation of sensory perception of pain
regulation of synaptic transmission, glutamatergic
cellular response to electrical stimulus
chemical synaptic transmission
regulation of glutamate secretion
membrane depolarization
synaptic transmission, GABAergic
activation of MAPKKK activity
desensitization of G-protein coupled receptor protein signaling pathway
regulation of transcription, DNA-templated
protein phosphorylation
learning
negative regulation of locomotion
phosphatidylinositol-mediated signaling
regulation of long-term neuronal synaptic plasticity
positive regulation of long-term neuronal synaptic plasticity
cognition
