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mGluR2 (extracellular) Antibody (AGC-011-200UL) in ICC/IF
Expression of mGluR2 in rat PC12 cells - Cell surface detection of mGluR2 in live intact rat PC12 pheochromocytoma cells. A. Extracellular staining of cells with Anti-mGluR2 (extracellular) Antibody (#AGC-011), (1:100), followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody (red). B. Live view of the cells. C. Merge of A and B.
产品信息
AGC-011-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SLSRGADGSRHIC, corresponding to amino acids 109-121 of rat mGluR2, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G protein coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member B; glutamate receptor; glutamate receptor homolog; glutamate receptor, metabotropic 2; M mGlu2; Metabotropic; Metabotropic glutamate receptor 2; mGluR2
基因别名: 4930441L02Rik; GLUR2; GPRC1B; GRM2; mGlu2; MGLUR2; mGluR7
UniProt ID: (Human) Q14416, (Mouse) Q14BI2, (Rat) P31421
Entrez Gene ID: (Human) 2912, (Mouse) 108068, (Rat) 24415
negative regulation of adenylate cyclase activity
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
glutamate secretion
regulation of synaptic transmission, glutamatergic
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
regulation of neurotransmitter secretion
