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n-Myc Antibody (PA5-87445) in IHC (P)
Immunohistochemistry analysis of n-Myc in paraffin-embedded mouse brain. Samples were incubated with n-Myc Polyclonal antibody (Product # PA5-87445). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol. 40x lens.
产品信息
PA5-87445
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 168-267 of human N-Myc/MYCN (NP_0053692)
偶联物
形式
Liquid
浓度
0.22 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804154
产品详细信息
Positive Samples: SH-SY5Y, Mouse heart, Rat brain; Cellular Location: Nucleus
Immunogen sequence: AGRAGAALPA ELAHPAAECV DPAVVFPFPV NKREPAPVPA APASAPAAGP AVASGAGIAA PAGAPGVAPP RPGGRQTSGG DHKALSTSGE DTLSDSDDED
靶标信息
N-Myc protein is member of the MYC family of transcription factor proteins with a basic helix-loop-helix (bHLH) domain. N-Myc is similarly regulated and functionally complementary to C-Myc in the context of various cellular growth and differentiation processes. MYCN gene is considered the hallmark of neuroblastoma, amplification and overexpression of the MYCN proto-oncogene occurs in approximately 20% of neuroblastomas and is associated with advanced stage disease, rapid tumor progression, and poor prognosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc); Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc); bHLHe37; Class E basic helix-loop-helix protein 37; N-myc proto-oncogene protein; neuroblastoma MYC oncogene; neuroblastoma myc-related oncogene 1; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene; oncogene NMYC; oncogene pp65/67; pp65/67; v-myc myelocytomatosis viral related oncogene, neuroblastoma derived
基因别名: BHLHE37; c-nmyc; MODED; MYCN; N-myc; Nmuc1; NMYC; Nmyc-1; Nmyc1; ODED
UniProt ID: (Human) P04198, (Mouse) P03966, (Rat) Q63379
Entrez Gene ID: (Human) 4613, (Mouse) 18109, (Rat) 298894
cartilage condensation
positive regulation of mesenchymal cell proliferation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of gene expression
positive regulation of cell death
lung development
embryonic digit morphogenesis
regulation of auditory receptor cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic skeletal system morphogenesis
negative regulation of astrocyte differentiation
branching morphogenesis of an epithelial tube
negative regulation of reactive oxygen species metabolic process
regulation of transcription, DNA-templated
positive regulation of cell proliferation
