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Application
Product Details
PA5-78147
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human p130. The exact sequence is proprietary.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2736509
Product Specific Information
Positive Control: Jurkat, Jurkat nuclear
Predicted Reactivity: Bovine (92%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 130 kDa retinoblastoma-associated protein; FLJ26459; P130; PPAR-alpha-interacting complex protein 128; PRB2; PRIC128; rb2 p130; RBR-2; retinoblastoma-like 2; Retinoblastoma-like protein 2; Retinoblastoma-related protein 2
Gene Aliases: P130; PRB2; RB2; RBL2; RBR-2
UniProt ID: (Human) Q08999, (Mouse) Q64700, (Rat) O55081
Entrez Gene ID: (Human) 5934, (Mouse) 19651, (Rat) 81758
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
negative regulation of gene expression
covalent chromatin modification
regulation of lipid kinase activity
regulation of transcription, DNA-templated
cell cycle
chromatin modification
regulation of cell cycle
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