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产品信息
PA5-142831
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-RRGPHRNPGPGDDD.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2933474
产品详细信息
Additional Information: This antibody is expected to recognize isoform p19ARF (NP_034007.1) only.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
靶标信息
In humans, the multiple tumor suppressor 1 locus (MTS1) encodes two unrelated genes, p16INK4a and p19ARF. Although both act as cell proliferation inhibitors, their mechanisms of action are different. p19ARF works as part of a p53-dependent pathway to counter uncontrolled proliferation and oncogenic signals. Mice lacking the p19ARF gene rapidly develop a broad spectrum of tumors. This result indicates that p19ARF is an important tumor suppressor. In addition, p19ARF helps prevent transforming signals from various onocoproteins via the p53 regulatory loop. These studies and others display the importance of p19ARF in cell cycle control and tumor suppression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alternative reading frame; ARF; CDK4I; cdkn2a; cdkn2a {ECO:0000312|EMBL:AAL76336.1, ECO:0000312|RGD:2323}; cdkn2a {ECO:0000312|EMBL:AAL76338.1, ECO:0000312|RGD:2323}; cell cycle inhibitor; cell cycle regulator; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); Cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2a p16Ink4a; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 1; cyclin-dependent kinase inhibitor 2A, isoform 2; cyclin-dependent kinase inhibitor 2A, isoform 3; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor protein; mitochondrial smARF; p16; p16-INK4; p16-INK4a; p19ARF; Tumor suppressor ARF
基因别名:
Arf; ARF-INK4a; Cdkn2a; INK4A; INK4a-ARF; Ink4a/Arf; MTS1; p16; p16(INK4a); p16Cdkn2a; P16ink4a; p19
UniProt ID: (Mouse) Q64364, (Rat) Q9R0Z3
Entrez Gene ID: (Mouse) 12578, (Rat) 25163
p53 binding
DNA binding
transcription factor activity, sequence-specific DNA binding
cyclin-dependent protein serine/threonine kinase inhibitor activity
protein binding
transcription factor binding
protein kinase binding
poly(A) RNA binding
protein N-terminus binding
NF-kappaB binding
ubiquitin-protein transferase inhibitor activity
MDM2/MDM4 family protein binding
regulation of cyclin-dependent protein serine/threonine kinase activity
G1/S transition of mitotic cell cycle
protein polyubiquitination
mitophagy
negative regulation of cell-matrix adhesion
transcription, DNA-templated
regulation of transcription, DNA-templated
rRNA processing
negative regulation of protein kinase activity
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell cycle
cell cycle arrest
aging
cell aging
negative regulation of cell proliferation
epidermis development
apoptotic mitochondrial changes
rRNA transcription
response to organonitrogen compound
regulation of G2/M transition of mitotic cell cycle
regulation of gene expression
response to organic cyclic compound
negative regulation of cell growth
negative regulation of B cell proliferation
regulation of protein stability
protein destabilization
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein binding
negative regulation of immature T cell proliferation in thymus
positive regulation of protein sumoylation
negative regulation of mammary gland epithelial cell proliferation
positive regulation of smooth muscle cell apoptotic process
somatic stem cell population maintenance
senescence-associated heterochromatin focus assembly
negative regulation of phosphorylation
response to drug
glucose homeostasis
positive regulation of apoptotic process
positive regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of nucleocytoplasmic transport
regulation of protein export from nucleus
somatic stem cell division
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
negative regulation of ubiquitin-protein transferase activity
mitochondrial depolarization
positive regulation of apoptotic process involved in mammary gland involution
cellular response to hydrogen peroxide
protein K63-linked ubiquitination
positive regulation of cell cycle arrest
cellular senescence
replicative senescence
positive regulation of protein localization to nucleus
positive regulation of signal transduction by p53 class mediator
regulation of apoptotic DNA fragmentation
negative regulation of proteolysis involved in cellular protein catabolic process
regulation of protein targeting to mitochondrion
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of macrophage apoptotic process
positive regulation of cellular senescence
Ras protein signal transduction
response to organic substance
cerebellum development
