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Invitrogen

p73 Polyclonal Antibody

查看其他21个p73抗体
说明书
实验方案
技术支持
说明书
实验方案
技术支持

产品信息

PA5-28931

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
-

免疫组化（石蜡） (IHC (P))

1:100-1:1,000
-

免疫细胞化学 (ICC/IF)

1:100-1:1,000
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fragment corresponding to a region within amino acids 11 and 407 of Human p73
查看免疫原

偶联物

Unconjugated

形式

Liquid

浓度

0.89 mg/mL

纯化类型

Antigen affinity chromatography

保存液

0.1M tris glycine, pH 7, with 10% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2546407

产品详细信息

Recommended positive controls: 293T, A431, Jurkat, Raji.

Predicted reactivity: Rat (94%), Zebrafish (80%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

P73 (TP73) participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: OTTHUMP00000003479; OTTHUMP00000003480; p53-like transcription factor; p53-related protein; RP23-254N4.10; Tumor protein p73

基因别名: P73; TP73

UniProt ID: (Human) O15350

Entrez Gene ID: (Human) 7161

功能
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding p53 binding chromatin binding damaged DNA binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding protein kinase binding identical protein binding transcription regulatory region DNA binding metal ion binding P53-like transcription factor
参与通路
negative regulation of transcription from RNA polymerase II promoter activation of MAPK activity kidney development mismatch repair transcription from RNA polymerase II promoter cellular response to DNA damage stimulus DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator cell cycle arrest regulation of mitotic cell cycle intrinsic apoptotic signaling pathway in response to DNA damage response to X-ray response to organonitrogen compound response to gamma radiation regulation of gene expression viral process mitotic G1 DNA damage checkpoint cellular response to UV response to drug intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process negative regulation of JUN kinase activity negative regulation of neuron apoptotic process negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of oligodendrocyte differentiation protein tetramerization negative regulation of cardiac muscle cell proliferation positive regulation of cell cycle arrest positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway regulation of signal transduction by p53 class mediator
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