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Invitrogen
pro-Brain Natriuretic Peptide Monoclonal Antibody (15F11)
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pro-Brain Natriuretic Peptide Antibody (MA1-20626) in WB
Detection of human recombinant proBNP expressed mammalian cells in Western blotting by different monoclonal antibodies after Tricine-SDS gel electrophoresis. Antigen: recombinant proBNP expressed in mammalian cells, 0.15 ug; Lane 1: pro-Brain Natriuretic Peptide Monoclonal Antibody (5B6) (Product # MA1-20622); Lane 2: pro-Brain Natriuretic Peptide Monoclonal Antibody (15F11) (Product # MA1-20626); Lane 3: p... View More
产品信息
MA1-20626
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
15F11
抗原
Synthetic peptide corresponding to residues E(13) T S G L Q E Q R N H L Q G K(27) of human proBNP.
偶联物
形式
Liquid
浓度
5.8 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
4° C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_560694
产品详细信息
MA1-20626 detects proBNP in human samples.
靶标信息
In cardiac tissue brain natriuretic peptide (BNP) is synthesized as 134 amino acid precursor (prepro-BNP), which is cleaved by proteases to form a 26 aa "signal" peptide and a 108 aa pro-BNP. Proteolytic digestion of pro-BNP results in formation of 76 aa amino-terminal NT-proBNP and biologically active 32 aa BNP hormone molecule. Both proBNP and NTproBNP circulate in human plasma and have been proposed as markers for early diagnosis of left ventricular dysfunction as well as prognostic markers of possible cardiac complications at patients with heart failure.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BNP32; Brain natriuretic factor prohormone; brain type natriuretic peptide; Gamma-brain natriuretic peptide; Iso-ANP; natriuretic peptide precursor B; Natriuretic peptides B; natriuretic protein; NTproBNP; preproBNP
基因别名: BNP; NPPB
UniProt ID: (Human) P16860
Entrez Gene ID: (Human) 4879
cGMP biosynthetic process
cell surface receptor signaling pathway
receptor guanylyl cyclase signaling pathway
body fluid secretion
regulation of blood pressure
negative regulation of angiogenesis
negative regulation of cell growth
positive regulation of urine volume
positive regulation of renal sodium excretion
regulation of vasodilation
regulation of vascular permeability
