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AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Axin-1; Axis inhibition protein 1; axis inhibitor 1; fused, mouse, homolog of; GSK-3beta interacting protein rAxin; hAxin; LA16c-314G4.3; MGC52315; Protein Fused; protein phosphatase 1, regulatory subunit 49; rAxin
基因别名: AI316800; AXIN; AXIN1; Fu; fused; Kb; Ki; kinky; knobbly; PPP1R49
UniProt ID: (Human) O15169, (Rat) O70239, (Mouse) O35625
Entrez Gene ID: (Human) 8312, (Rat) 79257, (Mouse) 12005