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CD6 Antibody (MA5-17047) in IHC (P)
Immunohistochemical analysis of paraffin-embedded stomach cancer tissues using CD6/TP120 monoclonal antibody (Product # MA5-17047) followed with DAB staining.
产品信息
MA5-17047
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
6B9
抗原
Purified recombinant fragment of human CD6 (amino acids: 472-668) expressed in E. Coli.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2538519
产品详细信息
MA5-17047 targets CD6 in IHC, indirect ELISA, and WB applications and shows reactivity with Human samples.
The MA5-17047 immunogen is purified recombinant fragment of human CD6 (amino acids: 472-668) expressed in E. Coli.
MA5-17047 detects CD6 which has a predicted molecular weight of approximately 71.8kDa.
靶标信息
CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD6; CD6 antigen; FLJ44171; T-cell differentiation antigen CD6; T12; TP120
基因别名: CD6; TP120
UniProt ID: (Human) P30203
Entrez Gene ID: (Human) 923
immunological synapse formation
adaptive immune response
acute inflammatory response to antigenic stimulus
receptor-mediated endocytosis
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
lipopolysaccharide-mediated signaling pathway
response to lipopolysaccharide
positive regulation of T cell proliferation
innate immune response
positive regulation of cytokine production involved in inflammatory response
