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Proteintech

DVL1 Polyclonal Antibody

8 References

View all (8) DVL1 antibodies

Datasheet

Protocols

Tech Support

Catalog # 27384-1-AP

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150 µL

Datasheet

Protocols

Tech Support

Antibody Testing Data (6)

Application

DVL1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 6

DVL1 Antibody (27384-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human prostate cancer tissue slide using 27384-1-AP (DVL1 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

27384-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DVL1 Fusion Protein Ag26055 (283-416 aa encoded by BC050454)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LGQGYPYQY PGPPPCFPPA YQDPGFSYGS GSTGSQQSEG SKSSGSTRSS RRAPGREKER RAAGAGGSGS ESDHTAPSGV GSSWRERPAG QLSRGSSPRS QASATAPGLP PPHPTTKAYT VVGGPPGGPP VRELA (283-416 aa encoded by BC050454)

Target Information

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cellproliferation, acting as a transducer molecule for developmentalprocesses, including segmentation and neuroblast specification.DVL1 is a candidate gene for neuroblastomatous transformation. TheSchwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2Ahave been mapped to the same region as DVL1. The phenotypes ofthese diseases may be consistent with defects which might beexpected from aberrant expression of a DVL gene during development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Selenium Deficiency Leads to Changes in Renal Fibrosis Marker Proteins and Wnt/β-Catenin Signaling Pathway Components.

Biological trace element research

Lin T,Tao J,Chen Y,Zhang Y,Li F,Zhang Y,Han X,Zhao Z,Liu G,Li H

Tue Mar 01 00:00:00 UTC 2022

ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.

Journal of experimental & clinical cancer research : CR

Dong S,Liang S,Cheng Z,Zhang X,Luo L,Li L,Zhang W,Li S,Xu Q,Zhong M,Zhu J,Zhang G,Hu S

Sat Jan 08 00:00:00 UTC 2022

Excess folic acid supplementation before and during pregnancy and lactation activates β-catenin in the brain of male mouse offspring.

Brain research bulletin

Wu Q,Zhou D,Wu R,Shi R,Shen X,Jin N,Gu J,Gu JH,Liu F,Chu D

Sat Jan 01 00:00:00 UTC 2022

The m⁶ A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Yu J,She Y,Yang L,Zhuang M,Han P,Liu J,Lin X,Wang N,Chen M,Jiang C,Zhang Y,Yuan Y,Ji SJ

Mon Nov 01 00:00:00 UTC 2021

Lycopene-Loaded Microemulsion Regulates Neurogenesis in Rats with Aβ-Induced Alzheimer's Disease Rats Based on the Wnt/β-catenin Pathway.

Neural plasticity

Ning WJ,Lv RJ,Xu N,Hou XY,Shen C,Guo YL,Fan ZY,Cao N,Liu XP

Fri Feb 04 00:00:00 UTC 2022

cDNA expression library screening revealed novel functional genes involved in clear cell carcinogenesis of the ovary in vitro.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

Yamada Y,Miyamoto T,Higuchi S,Ono M,Kobara H,Asaka R,Ando H,Suzuki A,Shiozawa T

Fri Jan 01 00:00:00 UTC 2021

Dishevelled-1 regulated apoptosis through NF-κB in cerebral ischemia/reperfusion injury in rats.

Neuroscience letters

Zhang X,Zhang X,Li X,Ma J,Xie D,Jiang N

Mon Mar 23 00:00:00 UTC 2020

Transcription factor AP-4 promotes tumorigenic capability and activates the Wnt/β-catenin pathway in hepatocellular carcinoma.

Theranostics

Song J,Xie C,Jiang L,Wu G,Zhu J,Zhang S,Tang M,Song L,Li J

Mon Aug 19 00:00:00 UTC 2019

Transcription factor AP-4 promotes tumorigenic capability and activates the Wnt/β-catenin pathway in hepatocellular carcinoma.

Theranostics

Song J,Xie C,Jiang L,Wu G,Zhu J,Zhang S,Tang M,Song L,Li J

Mon Aug 19 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: dishevelled 1 (homologous to Drosophila dsh); dishevelled, dsh homolog 1; Dishevelled-1; Dishevelled-1-like; DSH homolog 1; DSH homolog 1-like; MGC54245; RP5-890O3.5; Segment polarity protein dishevelled homolog DVL-1

Gene Aliases: DRS2; DVL; DVL1; DVL1L1; DVL1P1; mKIAA4029

UniProt ID: (Human) O14640, (Mouse) P51141

Entrez Gene ID: (Human) 1855, (Mouse) 13542

Function(s)

molecular_function frizzled binding protein binding beta-catenin binding enzyme binding protein kinase binding identical protein binding Rac GTPase binding scaffold/adaptor protein

Process(es)

regulation of neurotransmitter levels positive regulation of protein phosphorylation transcription from RNA polymerase II promoter negative regulation of protein kinase activity neurotransmitter secretion axon guidance synapse assembly heart development neuromuscular junction development positive regulation of neuron projection development neural tube development convergent extension involved in neural plate elongation positive regulation of Wnt signaling pathway cytoplasmic microtubule organization negative regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein localization to nucleus social behavior protein localization to microtubule intracellular signal transduction receptor clustering positive regulation of transcription, DNA-templated collateral sprouting axon extension dendrite morphogenesis synapse organization protein stabilization canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway prepulse inhibition skeletal muscle acetylcholine-gated channel clustering negative regulation of canonical Wnt signaling pathway cochlea morphogenesis planar cell polarity pathway involved in neural tube closure positive regulation of canonical Wnt signaling pathway positive regulation of protein localization to synapse regulation of cellular protein localization beta-catenin destruction complex disassembly

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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