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PAK1IP1 Antibody (PA5-56349) in IHC (P)
Immunohistochemical analysis of PAK1IP1 in human colon using PAK1IP1 Polyclonal Antibody (Product # PA5-56349) shows strong cytoplasmic and nuclear positivity in glandular cells.
产品信息
PA5-56349
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2645181
产品详细信息
Immunogen sequence: VWLDKVADMK ESLPPAAEPS PVSKEQSKIG KKEPGDTVHK EEKRSKPNTK KRGLTGDSKK ATKES
Highest antigen sequence identity to the following orthologs: Mouse - 51%, Rat - 43%.
靶标信息
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly (PubMed:24120868). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hPIP1; p21-activated protein kinase-interacting protein 1; PAK/PLC-interacting protein 1; PAK1-interacting protein 1; RP11-421M1.5; WD repeat-containing protein 84
基因别名: bA421M1.5; hPIP1; MAK11; PAK1IP1; PIP1; WDR84
UniProt ID: (Human) Q9NWT1
Entrez Gene ID: (Human) 55003
