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Application
FIGURE: 1 / 3
Sodium Channel Pan Antibody (PA5-77723) in IHC
Immunohistochemistry analysis of Sodium Channel Pan in rat cerebellum. A) Samples were probed with Sodium Channel Pan polyclonal antibody (Product # PA5-77723) and incubated with parvalbumin (green). B) Brain section stained image. C) Merged image of Panels A and B.
Product Details
PA5-77723
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide TEEQKKYYNAMKKLGSKK(C), corresponding to amino acid residues 1501-1518 of rat Nav 1.1
Conjugate
Unconjugated
Form
Lyophilized
Concentration
0.95 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2736645
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
Target Information
Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability. NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV alpha subunits have been cloned and named NaV1.1-NaV1.9. The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9). Mammalian sodium channels are heterotrimers, composed of a central, pore-forming alpha subunit and two auxiliary beta subunits. The expression of the alpha subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain beta 1 through beta 4 subunits, whereas sodium channels in adult skeletal muscle have only the beta 1 subunit.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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