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产品信息
PA5-43989
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N-terminal of human TMPRSS6 (aa 71-120).
偶联物
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2606885
产品详细信息
Peptide sequence: LLWYFLGYKA EVMVSQVYSG SLRVLNRHFS QDLTRRESSA FRSETAKAQK
Sequence homology: Cow: 100%; Dog: 93%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%
靶标信息
TMPRSS6 is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. TMPRSS6 can also activate urokinase-type plasminogen activator with low efficiency. TMPRSS6 may play a specialized role in matrix remodeling processes in liver. TMPRSS6 is required to sense iron deficiency. Overexpression of TMPRSS6 suppresses activation of the HAMP promoter. The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Matriptase-2; membrane-bound mosaic serine proteinase matriptase-2; Transmembrane protease serine 6; type II transmembrane serine protease 6
基因别名: IRIDA; TMPRSS6; UNQ354/PRO618
UniProt ID: (Human) Q8IU80
Entrez Gene ID: (Human) 164656
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
proteolysis
cellular iron ion homeostasis
extracellular matrix organization
negative regulation of BMP signaling pathway
membrane protein proteolysis
intracellular signal transduction
fibrinolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
iron ion homeostasis
self proteolysis
