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NeoBiotechnologies
14-3-3E/Tryptophan 5-Monooxygenase Recombinant Mouse Monoclonal Antibody (rYWHAE/8860)
产品信息
7531-MSM4-P1
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
rYWHAE/8860
抗原
Recombinant human full-length YWHAE protein
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive Control: HEK-293 or A-431 cell lines. Human brain prostate or placenta.
Cellular Location: Cytoplasm. Melanosome.
靶标信息
14-3-3 epsilon belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 14-3-3 epsilon; 14-3-3 protein epsilon; 14-3-3E; epididymis luminal protein 2; mitochondrial import stimulation factor L subunit; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide
基因别名: 14-3-3E; HEL2; KCIP-1; MDCR; MDS; YWHAE
UniProt ID: (Human) P62258
Entrez Gene ID: (Human) 7531
protein binding
potassium channel regulator activity
enzyme binding
protein domain specific binding
MHC class II protein complex binding
ubiquitin protein ligase binding
histone deacetylase binding
ion channel binding
poly(A) RNA binding
protein heterodimerization activity
phosphoserine binding
phosphoprotein binding
cadherin binding involved in cell-cell adhesion
scaffold/adaptor protein
G2/M transition of mitotic cell cycle
neuron migration
regulation of heart rate by hormone
protein targeting
viral process
substantia nigra development
hippocampus development
cerebral cortex development
hippo signaling
intracellular signal transduction
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of membrane repolarization
membrane organization
membrane repolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
cell-cell adhesion
regulation of cellular response to heat
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
regulation of potassium ion transmembrane transporter activity
negative regulation of peptidyl-serine dephosphorylation
