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Invitrogen
5-Hydroxymethylcytosine (5-hmC) Monoclonal Antibody (GT513)
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5-Hydroxymethylcytosine (5-hmC) Antibody (MA5-42319) in MeDIP
Methylated DNA Immunoprecipitation of 5-Hydroxymethylcytosine (5-hmC) in 500 ng of human genomic DNA mixed with methylated cytosine standard kit. Sample was incubated with monoclonal 5-Hydroxymethylcytosine (5-hmC) antibody (Product # MA5-42319) at a dilution of 1:500.
产品信息
MA5-42319
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
GT513
抗原
The immunogen used to generate this antibody corresponds to 5-Hydroxymethylcytosine / 5-hmC
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2911461
产品详细信息
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
靶标信息
5-hydroxymethylcytosine (5-hmC) has been recently discovered in mammalian DNA. 5-hmC results from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of oxygenases. Initially, the 5-hmC base had been identified in Purkinje neurons, in granule cells and embryonic stem cells where it is present at high levels (up to 0,6% of total nucleotides in Purkinje cells). A recent report indicates that 5-hmC is also abundant in brain tissue, especially in areas that are associated with higher cognitive functions.Early evidence suggests that 5-hmC may represent an intermediate in a new pathway which demethylates DNA, converting 5-mC to cytosine. Although its precise role has still to be shown, recent results indicate, however, that 5-hmC may play important roles distinct from 5-mC. This may open up entirely new perspectives in epigenetic studies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5-hmc; 5-HydroxymethylCytidine; 5hmc; C5H7N3O2
