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Mammalian apolipoprotein B mRNA undergoes site-specific Cto U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and acomplementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNPR family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: apo-B RNA editing protein; apobec-1 complementation factor; apobec-1 complementation factor (ACF) (ASP); Apobec-1 complementation factor APOBEC-1 stimulating protein; Apobec-1 complementation factor, APOBEC-1 stimulating protein; APOBEC-1 stimulating protein; APOBEC1 complementation factor; APOBEC1 complementation factort; APOBEC1-stimulating protein; MGC163391; RP11-564C4.2
基因别名: 1810073H04Rik; A1CF; A1cft; ACF; ACF64; ACF65; Apobec-1; APOBEC1CF; ASP
UniProt ID: (Human) A8K7G7, (Mouse) Q5YD48, (Rat) Q923K9
Entrez Gene ID: (Human) 29974, (Mouse) 69865, (Rat) 170912