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AANAT Antibody (PA5-75722) in IHC (P)
Immunohistochemistry analysis of AANAT in paraffin-embedded human breast carcinoma tissue (cytoplasmic strong positive staining) and negative control (right, with PBS only). Samples were incubated with AANAT polyclonal antibody (Product # PA5-75722) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
产品信息
PA5-75722
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues in Human AANAT
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2719450
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
Arylalkylamine N-Acetyltransferase (AANAT) is the penultimate enzyme is melatonin synthesis. Hormonal melatonin has been implicated in sleep and circadian clock function. Large changes in the abundance of AANAT are believed to be responsible for the large day/night rhythms in melatonin synthesis in the pineal gland and retina. Most research shows that AANAT activity is regulated by controlling the steady-state levels of the protein. Recent research, however, suggests that another mechanism may also play a role in controlling melatonin production without altering AANAT protein and activity. This mechanism may explain the sudden physiological increase in circulating melatonin observed at the onset of the dark period in humans.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AA-NAT; Aralkylamine N-acetyltransferase; arylakylamine N-acetyltransferase; Arylalkylamine N - acetyltransferase (Serotonin N - acetyltransferase); arylalkylamine N-acetyltransferase; Seretonin N-acetyltransferase; Serotonin acetylase; Serotonin N-acetyltransferase
基因别名: AA-NAT; AANAT; DSPS; Nat4; SNAT
UniProt ID: (Human) Q16613, (Rat) Q64666
Entrez Gene ID: (Human) 15, (Rat) 25120
N-terminal protein amino acid acetylation
circadian rhythm
photoperiodism
response to zinc ion
melatonin biosynthetic process
response to insulin
response to cytokine
response to prostaglandin E
indolalkylamine biosynthetic process
response to copper ion
response to corticosterone
response to calcium ion
cellular response to cAMP
response to light stimulus
response to organic cyclic compound
entrainment of circadian clock by photoperiod
response to cAMP
