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The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Apoptosis-antagonizing transcription factor; Protein AATF; Rb-binding protein Che-1; Traube protein
基因别名: 4933415H02Rik; 5830465M17Rik; AATF; BFR2; CHE-1; CHE1; DED; HSPC277; Trb
UniProt ID: (Human) B3KQ26, (Mouse) Q9JKX4
Entrez Gene ID: (Human) 26574, (Mouse) 56321