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ABCA1 Antibody (PA5-22906) in IHC (P)
Hepatology communications 2019 -
Figure 1 Quantitative proteomic analysis identifies significantly down-regulated lipid transporter proteins in SAH. (A) Partial list of proteins differentially regulated (>1.5-fold; P < 0.05) between SAH, AC, HC, and its GO analysis, which documents enrichment of lipid transporters in SAH. (B) KEGG enrichment analysis of the up-regulated (n = 32) and down-regulated (n = 176) proteins in patients with SAH r... View More
产品信息
PA5-22906
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Chicken,
Horse,
Hamster,
Human,
Mustelid,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Partial peptide sequence (peptide used resides somewhere between a.a 1100-1300) of the human ABCA1 gene. Actual immunogen sequence is proprietary information.
偶联物
形式
Liquid
浓度
0.81 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.05% sodium azide
保存条件
4° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11155833
靶标信息
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ABC 1; ABC 1 antibody; ABC Transporter 1; ABC-1; ABC1 antibody; ATP-binding cassette 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ATP-binding cassette transporter A1; ATP-binding cassette, sub-family A (ABC1), member 1; CERP antibody; Cholesterol efflux regulatory protein; membrane-bound; Phospholipid-transporting ATPase ABCA1
基因别名: ABC-1; ABC1; ABCA1; CERP; HDLDT1; TGD
UniProt ID: (Human) O95477, (Mouse) P41233
receptor binding
protein binding
ATP binding
phospholipid binding
phospholipid transporter activity
anion transmembrane transporter activity
cholesterol binding
cholesterol transporter activity
syntaxin binding
small GTPase binding
apolipoprotein binding
apolipoprotein A-I binding
apolipoprotein A-I receptor activity
ATPase activity, coupled to transmembrane movement of substances
ATPase binding
nucleotide binding
transporter activity
ATPase activity
ATP-binding cassette (ABC) transporter
primary active transporter
transporter
peptide secretion
protein lipidation
phagocytosis, engulfment
lysosome organization
G-protein coupled receptor signaling pathway
response to nutrient
cholesterol metabolic process
negative regulation of macrophage derived foam cell differentiation
positive regulation of cholesterol efflux
negative regulation of cholesterol storage
endosomal transport
positive regulation of cAMP biosynthetic process
intracellular cholesterol transport
regulation of Cdc42 protein signal transduction
cholesterol efflux
phospholipid efflux
high-density lipoprotein particle assembly
response to laminar fluid shear stress
apolipoprotein A-I-mediated signaling pathway
lipoprotein metabolic process
response to drug
cholesterol homeostasis
reverse cholesterol transport
phospholipid translocation
interleukin-1 beta secretion
phospholipid homeostasis
response to low-density lipoprotein particle
platelet dense granule organization
cellular response to lipopolysaccharide
cellular response to retinoic acid
cellular response to cholesterol
anion transmembrane transport
transport
phospholipid transport
cholesterol transport
lipoprotein biosynthetic process
transmembrane transport
response to high density lipoprotein particle
ion transmembrane transport
