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产品信息
PA1-9535
产品规格
种属反应
Human
宿主/亚型
Chicken
/ IgY
分类
Polyclonal
类型
Antibody
抗原
Purified recombinant ABCG1 corresponding to the chromosome 21 gene (Human).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
IgY fraction
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2220189
产品详细信息
PA1-9535 detects ABCG1 in human samples.
PA1-9535 has been successfully used in Western blot procedures. By Western blot, PA1-9535 detects a 53 kDa protein representing ABCG1.
PA1-9535 immunogen is a purified recombinant ABCG1 corresponding to the chromosome 21 gene (Human).
靶标信息
ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. The ABC transporter ABCG1 (ABC8) is expressed on the cell surface and in intracellular compartments of cholesterol-laden macrophages and is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. In contrast, lipid efflux in cholesterol-laden macrophages, mediated by the cholesterol acceptor HDL(3), suppresses the expression of ABCG1.
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生物信息学
蛋白别名: ABC transporter 8; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; ATP-binding cassette transporter member 1 of subfamily G; ATP-binding cassette, sub-family G (WHITE), member 1; homolog of Drosophila white; MGC34313; White protein homolog; white protein homolog (ATP-binding cassette transporter 8)
基因别名: ABC8; ABCG1; WHITE1; WHT1
UniProt ID: (Human) P45844
Entrez Gene ID: (Human) 9619
ATP binding
phospholipid binding
phospholipid transporter activity
cholesterol binding
cholesterol transporter activity
toxin transporter activity
sterol-transporting ATPase activity
glycoprotein transporter activity
protein homodimerization activity
ADP binding
protein heterodimerization activity
protein dimerization activity
ATP-binding cassette (ABC) transporter
primary active transporter
transporter
regulation of transcription, DNA-templated
cholesterol metabolic process
detection of hormone stimulus
response to organic substance
negative regulation of macrophage derived foam cell differentiation
regulation of cholesterol esterification
positive regulation of cholesterol efflux
negative regulation of cholesterol storage
intracellular cholesterol transport
cholesterol efflux
phospholipid efflux
response to lipid
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
glycoprotein transport
lipoprotein metabolic process
cholesterol homeostasis
amyloid precursor protein catabolic process
reverse cholesterol transport
positive regulation of cholesterol biosynthetic process
transmembrane transport
phospholipid homeostasis
response to high density lipoprotein particle
toxin transport
