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This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Abelson interactor 1; Abi-1; Abl interactor 1; e3B1; EL2; eps8 binding protein (e3B1), alternatively spliced; Eps8 SH3 domain-binding protein; Eps8-binding protein; HS3; SPH3; SPTA
基因别名: Abi1; E3b1
UniProt ID: (Rat) Q9QZM5
Entrez Gene ID: (Rat) 79249
分子生物学功能: scaffold/adaptor protein