Search Thermo Fisher Scientific
图: 1 / 2
Positive test controls include: HeLa, SW620, HepG2, Mouse liver, Mouse brain, Mouse kidney, Rat brain, Rat kidney. The target is usually found in the following locations: Cytoplasm.
Immunogen sequence: GLTDAFHNCH MGITAENVAK KWQVSREDQD KVAVLSQNRT ENAQKAGHFD KEIVPVLVST RKGLIEVKTD EFPRHGSNIE AMSKLKPYFL TDGTGTVTPA N
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: acetoacetyl Coenzyme A thiolase; Acetyl-CoA acetyltransferase, cytosolic; Acetyl-CoA transferase-like protein; acetyl-Coenzyme A acetyltransferase 2; acetyl-Coenzyme A acetyltransferase 3; AE1; BND3; Cytosolic acetoacetyl-CoA thiolase; DI; EMPB3; EPB3; RTA1A; SW; t-complex protein 1, related sequence 1; WD; WD1; WR
基因别名: Ab2-076; ACAT2; Acat3; ACTL; AW742799; Tcp-1x; Tcp1-rs1
UniProt ID: (Human) Q9BWD1, (Rat) Q5XI22, (Mouse) Q8CAY6
Entrez Gene ID: (Human) 39, (Rat) 308100, (Mouse) 110460