Invitrogen

ACE Polyclonal Antibody

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说明书
实验方案
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产品信息

PA5-78711

应用
建议稀释比
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免疫印迹 (WB)

0.1-0.5 µg/mL
-

免疫组化（石蜡） (IHC (P))

0.5-1 µg/mL
-

免疫组化（冰冻） (IHC (F))

0.5-1 µg/mL
-

免疫细胞化学 (ICC/IF)

2 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

E.coli-derived human ACE recombinant protein (Position: K651-Y864).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 5mg BSA

内含物

0.05mg sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2745827

产品详细信息

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

靶标信息

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes-the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: ACE; angiotensin 1 converting enzyme 1; angiotensin converting enzyme, somatic isoform; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme 1; angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript; angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1); Angiotensin-converting enzyme; carboxycathepsin; CD143; CD143 antigen; dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme); Dipeptidyl carboxypeptidase I; dipeptidyl peptidase; Kininase II; MGC26566; peptidase P; testicular ECA

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基因别名: ACE; ACE1; AW208573; CD143; DCP; DCP1; ICH; MVCD3; StsRR92

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UniProt ID: (Human) P12821, (Mouse) P09470, (Rat) P47820

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Entrez Gene ID: (Human) 1636, (Mouse) 11421, (Rat) 24310

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功能
endopeptidase activity carboxypeptidase activity drug binding metallopeptidase activity exopeptidase activity tripeptidyl-peptidase activity peptidyl-dipeptidase activity zinc ion binding chloride ion binding mitogen-activated protein kinase kinase binding bradykinin receptor binding mitogen-activated protein kinase binding metallodipeptidase activity actin binding protein binding peptidase activity lytic transglycosylase activity mannosidase activity mannosyl-oligosaccharide mannosidase activity galactosidase activity glucosidase activity trehalase activity fucosidase activity hexosaminidase activity amylase activity hydrolase activity dextrin alpha-glucosidase activity starch alpha-glucosidase activity metal ion binding beta-glucanase activity beta-6-sulfate-N-acetylglucosaminidase activity glucan endo-1,4-beta-glucosidase activity metalloprotease protease protein modifying enzyme
参与通路
kidney development blood vessel remodeling angiotensin maturation angiotensin catabolic process in blood regulation of renal output by angiotensin neutrophil mediated immunity antigen processing and presentation of peptide antigen via MHC class I regulation of systemic arterial blood pressure by renin-angiotensin spermatogenesis regulation of blood pressure regulation of smooth muscle cell migration regulation of vasoconstriction mononuclear cell proliferation regulation of vasodilation hormone catabolic process peptide catabolic process beta-amyloid metabolic process arachidonic acid secretion heart contraction regulation of angiotensin metabolic process hematopoietic stem cell differentiation positive regulation of protein tyrosine kinase activity cell proliferation in bone marrow positive regulation of peptidyl-tyrosine autophosphorylation regulation of hematopoietic stem cell proliferation negative regulation of gap junction assembly positive regulation of peptidyl-cysteine S-nitrosylation positive regulation of systemic arterial blood pressure proteolysis peptide metabolic process posttranscriptional regulation of gene expression negative regulation of gene expression bradykinin catabolic process sensory perception of pain organ regeneration negative regulation of protein binding positive regulation of protein binding response to lipopolysaccharide vasoconstriction eating behavior positive regulation of apoptotic process lung alveolus development positive regulation of inflammatory response positive regulation of neurogenesis angiogenesis involved in coronary vascular morphogenesis negative regulation of calcium ion import response to hypoxia brain development female pregnancy aging male gonad development lung development response to nutrient levels response to laminar fluid shear stress response to drug cellular response to glucose stimulus response to dexamethasone response to thyroid hormone
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