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ACE2 Antibody (BS-23444R) in ICC/IF
A431 cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (ACE2) polyclonal Antibody, Unconjugated (bs-23444R) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.
产品信息
BS-23444R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human ACE2:351-450/805
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 1% BSA, 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
靶标信息
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ACE 2; ACE-related carboxypeptidase; ACEH; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; Angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; Angiotensin-converting enzyme-related carboxypeptidase; Metalloprotease MPROT15; peptidyl-dipeptidase A
基因别名: 2010305L05Rik; ACE2; ACEH; UNQ868/PRO1885
UniProt ID: (Human) Q9BYF1, (Mouse) Q8R0I0
Entrez Gene ID: (Human) 59272, (Mouse) 70008
regulation of cytokine production
angiotensin maturation
angiotensin catabolic process in blood
angiotensin-mediated drinking behavior
regulation of systemic arterial blood pressure by renin-angiotensin
tryptophan transport
regulation of vasoconstriction
receptor biosynthetic process
regulation of cell proliferation
regulation of vasodilation
viral entry into host cell
receptor-mediated virion attachment to host cell
regulation of inflammatory response
positive regulation of cardiac muscle contraction
positive regulation of gap junction assembly
regulation of cardiac conduction
positive regulation of reactive oxygen species metabolic process
proteolysis
negative regulation of smooth muscle cell proliferation
negative regulation of ERK1 and ERK2 cascade
