Invitrogen

ACE2 Monoclonal Antibody (CL4013)

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

1个已发表图片

3 篇参考文献

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说明书

实验方案

技术支持

说明书

实验方案

技术支持

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ACE2 Antibody (MA5-31394) in WB

Western Blot was performed using Anti-ACE2 Monoclonal Antibody (CL4013) (Product # MA5-31394) and a 120 kDa band corresponding to Angiotensin-converting enzyme 2 was observed across all cell lines tested except BJ and U2OS which are known to be low expressing (DOI: 10.3892/mmr.2014.2266). Membrane enriched extracts (50 µg lysate) of HaCaT (Lane 1), Hep G2 (Lane 2), RT-4 (Lane 3), BJ (Lane 4), U-2 OS (Lane 5), Mouse Testis (Lane 6), Mouse Testis (Lane 7), Rat Skeletal Muscle (Lane 8), Rat Skeletal Muscle (Lane 9) were electrophoresed using ... View More

ACE2 Antibody in Immunohistochemistry (IHC)

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ACE2 Antibody — Antibody specificity was demonstrated by detection of differential basal expression of the target across cell lines owing to their inherent genetic constitution. Relative expression of Angiotensin-converting enzyme 2 was observed in HaCaT, Hep G2 and RT4 but not in BJ and U-2 OS (DOI: 10.3892/mmr.2014.2266) using Anti-ACE2 Monoclonal Antibody (CL4013) (Product # MA5-31394) in Western Blot. {RE}

产品信息

MA5-31394

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

免疫组化 (IHC)

1:10,000-1:20,000

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

CL4013

抗原

Recombinant protein corresponding to Human ACE2

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.0 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2787030

产品详细信息

Immunogen sequence: MSSSSWLLLS LVAVTAAQST IEEQAKTFLD KFNHEAEDLF YQSSLASWNY NTNITEENVQ NMNNAGDKWS AFLKEQSTLA QMYPLQEIQN LTVKLQLQAL QQNGSSVLSE D

靶标信息

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

ACE inhibitors on ACE1, ACE2, and TMPRSS2 expression and spheroid attachment on human endometrial Ishikawa cells.

Reproductive biology

Fernando SR,Chen X,Cheng KW,Wong BP,Qi S,Jiang L,Kodithuwakku SP,Ng EH,Yeung WS,Lee KF

MA5-31394 was used in Immunohistochemistry to suggest that higher ACE2 expression was found in mid-secretory endometrium and the use of ACE inhibitors did not alter endometrial receptivity for embryo implantation.

Thu Sep 01 00:00:00 EDT 2022

ACE inhibitors on ACE1, ACE2, and TMPRSS2 expression and spheroid attachment on human endometrial Ishikawa cells.

Reproductive biology

Fernando SR,Chen X,Cheng KW,Wong BP,Qi S,Jiang L,Kodithuwakku SP,Ng EH,Yeung WS,Lee KF

Thu Sep 01 00:00:00 EDT 2022

SARS-CoV-2-Induced Pathology-Relevance to COVID-19 Pathophysiology.

Pathophysiology : the official journal of the International Society for Pathophysiology

Zinserling VA,Semenova NY,Bikmurzina AE,Kruglova NM,Rybalchenko OV,Markov AG

MA5-31394 was used in Immunohistochemistry to illustrate some aspects of pathogenesis by the appropriate histopathological changes detected in observations.

Fri Jun 10 00:00:00 EDT 2022

Viral infiltration of pancreatic islets in patients with COVID-19.

Nature communications

Steenblock C,Richter S,Berger I,Barovic M,Schmid J,Schubert U,Jarzebska N,von Mässenhausen A,Linkermann A,Schürmann A,Pablik J,Dienemann T,Evert K,Rodionov RN,Semenova NY,Zinserling VA,Gainetdinov RR,Baretton G,Lindemann D,Solimena M,Ludwig B,Bornstein SR

MA5-31394 was used in Immunohistochemistry to show that even in the absence of manifest new-onset diabetes, necroptotic cell death, immune cell infiltration and SARS-CoV-2 viral infection of pancreatic beta-cells may contribute to varying degrees of metabolic dysregulation in patients with COVID-19.

Thu Jun 10 00:00:00 EDT 2021

生物信息学

蛋白别名: ACE 2; ACE-related carboxypeptidase; ACEH; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; Angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; Angiotensin-converting enzyme-related carboxypeptidase; Metalloprotease MPROT15; peptidyl-dipeptidase A

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基因别名: ACE2; ACEH; UNQ868/PRO1885

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UniProt ID: (Human) Q9BYF1

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Entrez Gene ID: (Human) 59272

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功能

virus receptor activity glycoprotein binding endopeptidase activity carboxypeptidase activity metallocarboxypeptidase activity protein binding metallopeptidase activity peptidyl-dipeptidase activity zinc ion binding metalloprotease

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