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产品信息
MA5-50302
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Cat,
Human,
Non-human primate
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1092
抗原
Recombinant protein encompassing a sequence within the N-terminus region of human ACE2. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3093931
靶标信息
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ACE 2; ACE-related carboxypeptidase; ACE2; ACEH; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; Angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; Angiotensin-converting enzyme-related carboxypeptidase; Metalloprotease MPROT15; peptidyl-dipeptidase A
基因别名: ACE2; ACEH; UNQ868/PRO1885
UniProt ID: (Human) Q9BYF1, (Cat) Q56H28
Entrez Gene ID: (Human) 59272, (Cat) 554349, (Dog) 480847
regulation of cytokine production
angiotensin maturation
angiotensin catabolic process in blood
angiotensin-mediated drinking behavior
regulation of systemic arterial blood pressure by renin-angiotensin
tryptophan transport
regulation of vasoconstriction
receptor biosynthetic process
regulation of cell proliferation
regulation of vasodilation
viral entry into host cell
receptor-mediated virion attachment to host cell
regulation of inflammatory response
positive regulation of cardiac muscle contraction
positive regulation of gap junction assembly
regulation of cardiac conduction
positive regulation of reactive oxygen species metabolic process
